Rabbit Polyclonal TSP4B antibody. N-terminal. Suitable for WB, IHC - Wmt and reacts with Zebrafish samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish thbs4b aa 1-350.
Images
Publications
Filter by
- JCI insight 7:2022A pathogenic mechanism associated with myopathies and structural birth defects involves TPM2-directed myogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJennifer McAdow,Shuo Yang,Tiffany Ou,Gary Huang,Matthew B Dobbs,Christina A Gurnett,Michael J Greenberg,Aaron N JohnsonPubMed 35579956
- Developmental dynamics : an official publication of the American Association of Anatomists 252:104-1232022Zebrafish Erc1b mediates motor innervation and organization of craniofacial muscles in control of jaw movement.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLauryn N Luderman,Mackenzie T Michaels,Daniel S Levic,Ela W KnapikPubMed 35708710
- Nature medicine 26:98-1092020Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGokhan Unlu et. al.PubMed 31932796
- FASEB journal : official publication of the Federa 33:9116-91302019Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish.Applications:Unspecified applicationReactive species:Unspecified reactive speciesErika Kague et. al.PubMed 31100023
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Zebrafish thbs4b aa 1-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q8JGW0
Reactivity data
Select an application| WB | IHC - Wmt | |
|---|---|---|
| Zebrafish | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Zebrafish | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
IHC - Wmt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Zebrafish | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response (By similarity).
Alternative names
thbs4, tsp4, thbs4b, Thrombospondin-4-B, Thbs4-B
Recommended products
Rabbit Polyclonal TSP4B antibody. N-terminal. Suitable for WB, IHC - Wmt and reacts with Zebrafish samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish thbs4b aa 1-350.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Zebrafish thbs4b aa 1-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q8JGW0
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
THBS4 also known as Thrombospondin-4 is a glycoprotein with a mass of approximately 105 kDa. It is part of the thrombospondin family which is known for binding to various cell surface receptors and components of the extracellular matrix. THBS4 is expressed in many tissues including the brain heart and skeletal muscle. Its structure allows it to interact with other proteins and play a role in cell-matrix communication.
- Biological function summary
THBS4 interacts with molecules in the extracellular matrix to regulate cellular functions such as adhesion migration and proliferation. It often operates within a complex network of proteins modulating cell interactions and tissue remodeling. This protein contributes to synaptic functions in the nervous system and soft tissue repair. The presence of THBS4 in different tissue types suggests it has diverse roles across the body's systems.
- Pathways
This protein is a component of the signaling pathways related to inflammatory and repair processes. THBS4 participates in the TGF-beta (Transforming Growth Factor-beta) signaling pathway which involves other proteins like TGF-beta itself and integrins. It influences wound healing and fibrosis through its effects on cellular behavior and signaling cascades.
- Associated diseases and disorders
Alterations in THBS4 levels can associate with conditions such as myocardial infarction and osteoarthritis. Abnormal expression or function of THBS4 can disrupt normal tissue repair and inflammation control contributing to disease progression. The protein's interaction with integrins and collagen is significant in understanding its role in these conditions highlighting its potential as a therapeutic target for modulating tissue repair and disease processes.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
Western blot - Anti-THBS4 antibody - N-terminal (ab211143)
7.5% SDS-PAGE
All lanes: Western blot - Anti-THBS4 antibody - N-terminal (ab211143) at 1/1000 dilution
All lanes: Zebrafish muscle whole cell lysate at 30 µg
Predicted band size: 106 kDa
IHC - Wholemount - Anti-THBS4 antibody - N-terminal (ab211143)
Wholemount immunohistochemical analysis of 2 days-post-fertilization zebrafish embryo labeling THBS4 with ab211143 at 1/100 dilution.
IHC - Wholemount - Anti-THBS4 antibody - N-terminal (ab211143)
Wholemount immunohistochemical analysis of 2 days-post-fertilization zebrafish embryo labeling THBS4 with ab211143 at 1/100 dilution.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com