AB233288

Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker

Lab Essentials
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(3 Publications)

Rabbit Polyclonal Thromboxane A2 receptor/TBXA2R antibody. Cytoplasm marker. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TBXA2R aa 1-350.

View Alternative Names

Thromboxane A2 receptor, TXA2-R, Prostanoid TP receptor, TBXA2R

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

Formalin-fixed, paraffin-embedded human pancreatic cancer tissue stained for Thromboxane A2 receptor/TBXA2R using ab233288 at 20 μg/mL in immunohistochemical analysis.

Secondary used : HRP-Linked Goat Anti-Rabbit IgG Polyclonal at 2 μg/ml. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Thromboxane A2 receptor/TBXA2R using ab233288 at 20 μg/mL in immunohistochemical analysis.

Secondary used : HRP-Linked Goat Anti-Rabbit IgG Polyclonal at 2 μg/ml. DAB staining.

Supplier Data

Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

All lanes:

Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (ab233288) at 1 µg/mL

All lanes:

Rat kidney tissue lysate

Secondary

All lanes:

HRP-linked Goat anti-Rabbit IgG polyclonal at 0.2 µg/mL

Predicted band size: 37 kDa

false

Supplier Data

Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

All lanes:

Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (ab233288) at 1 µg/mL

All lanes:

Recombinant human Thromboxane A2 receptor/TBXA2R

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TBXA2R aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

P21731

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "African green monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Thromboxane A2 receptor (TBXA2R) also known as the thromboxane prostanoid receptor is a G protein-coupled receptor with a molecular mass of approximately 70 kDa. This receptor is important for mediating the effects of thromboxane A2 a lipid-derived molecule involved in vasoconstriction and platelet aggregation. TBXA2R expresses predominantly in platelets smooth muscle cells and in some types of leukocytes. The receptor's activity is mediated through Gq proteins causing changes in intracellular calcium levels which trigger various cellular responses.

Biological function summary

Within the context of cellular signaling TBXA2R plays vital roles in hemostasis and thrombosis through its impact on platelet activation and vascular tone regulation. When thromboxane A2 binds to TBXA2R the receptor undergoes conformational changes activating intracellular signaling cascades that facilitate these physiological processes. TBXA2R operates as part of a signaling complex that includes other receptors and regulatory proteins modulating hemostatic balance and vascular reactivity.

Pathways

This receptor fits centrally into the arachidonic acid pathway influencing hemostatic and inflammatory responses. It closely interacts with cyclooxygenase enzymes particularly COX-1 involved in thromboxane A2 synthesis. TBXA2R also integrates into the prostaglandin synthesis pathway interacting with related prostanoid receptors sharing similar signaling mechanisms but differing physiological outcomes. These pathways reveal TBXA2R's significance as a cytoplasmic marker for activity related to vascular homeostasis.

TBXA2R exhibits key associations with cardiovascular diseases including atherosclerosis and myocardial infarction. The receptor’s role in promoting platelet aggregation makes it an interesting target in these pathologies where abnormal clotting adds to disease progression. Additionally TBXA2R connects with other proteins like integrins and inhibitors of cyclooxygenase representing therapeutic targets to modulate its activity and prevent thrombotic events and inflammatory responses associated with these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.. Isoform 1. Activates adenylyl cyclase.. Isoform 2. Inhibits adenylyl cyclase.

See full target information TBXA2R

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical neurology (Seoul, Korea) 20:580-590 PubMed39505310

2024

CGG Repeat Expansion in Causing Overlapping Oculopharyngodistal Myopathy and Neuronal Intranuclear Inclusion Disease With Diffusion Weighted Imaging Abnormality in the Cerebellum.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Ma,Huiqiu Zhang,Bing Meng,Jiangbo Qin,Hongye Liu,Xiaomin Pang,Rongjuan Zhao,Juan Wang,Xueli Chang,Junhong Guo,Wei Zhang

Frontiers in physiology 12:624967 PubMed33613315

2021

Downregulation of Soluble Guanylate Cyclase and Protein Kinase G With Upregulated ROCK2 in the Pulmonary Artery Leads to Thromboxane A2 Sensitization in Monocrotaline-Induced Pulmonary Hypertensive Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Suhan Cho,Hyun Namgoong,Hae Jin Kim,Rany Vorn,Hae Young Yoo,Sung Joon Kim

Clinical interventions in aging 15:537-545 PubMed32368020

2020

Influence of Ageing on Vascular Reactivity and Receptor Expression in Rabbit Aorta: A Complement to Elastocalcinosis and Smooth Muscle Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Nelson Ivan Cupitra,Juan C Calderón,Raul Narvaez-Sanchez

View all publications

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Product promise

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Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise