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AB134959

Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336]

3

(1 Review)

|

(3 Publications)

Rabbit Recombinant Monoclonal Thromboxane A2 receptor/TBXA2R antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

Thromboxane A2 receptor, TXA2-R, Prostanoid TP receptor, TBXA2R

1 Images
Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (AB134959)
  • WB

Unknown

Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (AB134959)

All lanes:

Western blot - Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] (ab134959) at 1/1000 dilution

Lane 1:

Human platelet lysate at 10 µg

Lane 2:

Human fetal kidney lysate at 10 µg

Lane 3:

Human fetal heart lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti rabbit at 10 µg

Predicted band size: 37 kDa

false

  • Carrier free

    Anti-Thromboxane A2 receptor/TBXA2R antibody [EPR7336] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7336

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Alternative Products

Primary Antibodies

AB233288

Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker

Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker (AB233288)

  • 0
  • 0

Complementary Products

Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

AB178454

Anti-Endothelin A Receptor/ET-A antibody [UMB-8-37-1]

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  • 4
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Primary Antibodies

AB154173

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Thromboxane A2 receptor (TBXA2R) also known as the thromboxane prostanoid receptor is a G protein-coupled receptor with a molecular mass of approximately 70 kDa. This receptor is important for mediating the effects of thromboxane A2 a lipid-derived molecule involved in vasoconstriction and platelet aggregation. TBXA2R expresses predominantly in platelets smooth muscle cells and in some types of leukocytes. The receptor's activity is mediated through Gq proteins causing changes in intracellular calcium levels which trigger various cellular responses.
Biological function summary

Within the context of cellular signaling TBXA2R plays vital roles in hemostasis and thrombosis through its impact on platelet activation and vascular tone regulation. When thromboxane A2 binds to TBXA2R the receptor undergoes conformational changes activating intracellular signaling cascades that facilitate these physiological processes. TBXA2R operates as part of a signaling complex that includes other receptors and regulatory proteins modulating hemostatic balance and vascular reactivity.

Pathways

This receptor fits centrally into the arachidonic acid pathway influencing hemostatic and inflammatory responses. It closely interacts with cyclooxygenase enzymes particularly COX-1 involved in thromboxane A2 synthesis. TBXA2R also integrates into the prostaglandin synthesis pathway interacting with related prostanoid receptors sharing similar signaling mechanisms but differing physiological outcomes. These pathways reveal TBXA2R's significance as a cytoplasmic marker for activity related to vascular homeostasis.

TBXA2R exhibits key associations with cardiovascular diseases including atherosclerosis and myocardial infarction. The receptor’s role in promoting platelet aggregation makes it an interesting target in these pathologies where abnormal clotting adds to disease progression. Additionally TBXA2R connects with other proteins like integrins and inhibitors of cyclooxygenase representing therapeutic targets to modulate its activity and prevent thrombotic events and inflammatory responses associated with these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.. Isoform 1. Activates adenylyl cyclase.. Isoform 2. Inhibits adenylyl cyclase.
See full target information TBXA2R
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

IUBMB life 72:492-504 PubMed31613419

2019

Overexpressed microRNA-103a-3p inhibits acute lower-extremity deep venous thrombosis via inhibition of CXCL12.

Applications

Unspecified application

Species

Unspecified reactive species

Shaoliang Sun,Shanyi Chai,Feng Zhang,Lu Lu

Diabetes & vascular disease research 15:528-540 PubMed30130976

2018

Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Azlina A Razak,Lopa Leach,Vera Ralevic

The Journal of allergy and clinical immunology 141:1259-1268.e11 PubMed28754608

2017

Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor-transmembrane protein 16A-voltage-dependent Ca channel axis and contribute to bronchial hyperresponsiveness in asthma.

Applications

WB

Species

Unspecified reactive species

Pei Wang,Wei Zhao,Jie Sun,Tao Tao,Xin Chen,Yan-Yan Zheng,Cheng-Hai Zhang,Zhong Chen,Yun-Qian Gao,Fan She,Ye-Qiong Li,Li-Sha Wei,Ping Lu,Cai-Ping Chen,Ji Zhou,Da-Quan Wang,Liang Chen,Xiao-Hao Shi,Linhong Deng,Ronghua ZhuGe,Hua-Qun Chen,Min-Sheng Zhu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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