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AB121122

Anti-THSD7A antibody

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(1 Publication)

Rabbit Polyclonal THSD7A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.

View Alternative Names

KIAA0960, THSD7A, Thrombospondin type-1 domain-containing protein 7A

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody (AB121122)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody (AB121122)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling THSD7A with ab121122 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody (AB121122)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody (AB121122)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling THSD7A with ab121122 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody (AB121122)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody (AB121122)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling THSD7A with ab121122 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody (AB121122)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody (AB121122)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pancreas tissue labelling THSD7A with ab121122 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THSD7A also known as Thrombospondin Type-1 Domain Containing Protein 7A is a glycoprotein with a mass of approximately 250 kDa. The glycoprotein is expressed mainly in the kidneys and brain and to some extent in the placenta and lungs. This expression pattern suggests its potential role in the vascular system and nervous tissues. THSD7A is localized at endothelial cells where it is thought to interact with the extracellular matrix.
Biological function summary

THSD7A influences cell adhesion and migration processes. It plays a significant role in angiogenesis promoting the formation and maintenance of blood vessels. This protein often partners with integrins forming a complex that modulates various cellular interactions essential for vessel stability and permeability. THSD7A's involvement in the developing circulatory system signifies its importance in embryonic growth and development.

Pathways

This protein intersects the angiogenesis and cell adhesion pathways. Within these contexts THSD7A interacts with other proteins such as vascular endothelial growth factor (VEGF) and integrins which are critical for the angiogenesis process. These interactions facilitate proper cell signaling that ensures blood vessel formation and repair stressing its functional significance in vascular biology.

THSD7A has links with membranous nephropathy an autoimmune kidney condition. Autoantibodies against THSD7A are found in a subset of patients with this disease linking it directly to disease pathology. Additionally given its role in angiogenesis abnormalities in THSD7A expression or function may also relate to cancer progression where angiogenic imbalance plays a pivotal role. Understanding THSD7A's connection with VEGF during these disease states highlights it as an important target for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Thrombospondin type-1 domain-containing protein 7A. Plays a role in actin cytoskeleton rearrangement.. Thrombospondin type-1 domain-containing protein 7A, soluble form. The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.
See full target information THSD7A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death and differentiation 30:1811-1828 PubMed37322264

2023

NKAP acts with HDAC3 to prevent R-loop associated genome instability.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Zhang,Jingwei Duan,Yang Li,Xiaoye Jin,Cheng Wu,Xiaohang Yang,Weiguo Lu,Wanzhong Ge
View all publications
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Product promise

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