AB14338

Anti-Thymosin beta 10 antibody

(1 Review)

(7 Publications)

Rabbit Polyclonal Thymosin beta 10 antibody. Suitable for ELISA and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human TMSB10 aa 1 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

PTMB10, THYB10, TMSB10, Thymosin beta-10

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ELISA

applications

Immunogen

Synthetic Peptide within Human TMSB10 aa 1 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P63313

Specificity

Human Thymosin B10 (aa 38-43). No cross reactivities with human Thymosin B4, Thymosin B9, Thymosin B15, Thymosin B4 (aa 1-4) peptide, or Thymosin B4 (aa 1-14).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/4000", "ELISA-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Constituents: Whole serum

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Thymosin beta 10 also known as TMSB10 is a small protein that plays a role in the dynamics of the cytoskeleton. It has a mass of approximately 5 kDa. TMSB10 is found in various tissues with high expression levels in the brain kidney and heart. Its function involves binding to actin monomers preventing polymerization and consequently regulating actin filament assembly in cells.

Biological function summary

TMSB10 significantly influences cell movement and proliferation. It serves as an actin-sequestering protein and is not generally part of a larger protein complex. TMSB10 promotes cell motility and plays an essential part in processes like wound healing and angiogenesis. Through these actions it helps in tissue regeneration and repair influencing the cell's structural organization and signaling.

Pathways

TMSB10 is involved in the actin cytoskeleton pathway and cellular signaling pathways that govern movement and shape changes in cells. Its interaction with actin places it in relation to actin-related protein (ARP) complexes such as Arp2/3 which facilitate actin filament branching. In addition TMSB10's regulation of actin dynamics links it to pathways involving proteins like cofilin which modulates actin filament turnover.

TMSB10 shows a connection to cancer and cardiovascular disorders. Elevated levels of TMSB10 have been associated with tumor progression due to its role in enhancing cell movement and metastasis. In cardiovascular disorders changes in TMSB10 expression can impact cardiac function due to its influence on actin dynamics. Proteins such as vascular endothelial growth factor (VEGF) interact with TMSB10 during pathological conditions further illustrating its role in disease mechanisms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

See full target information TMSB10

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Translational oncology 46:102026 PubMed38850800

2024

Can thymosin beta 10 function both as a non-invasive biomarker and chemotherapeutic target in human colorectal cancer?

Applications

Unspecified application

Species

Unspecified reactive species

Jian Yang,Xiaolong Yang,Tianyi Guo,Lingxiao Wang,Zhenxiang Zhao,Zhen Hu,Yaoping Li

International journal of oncology 56:1101-1114 PubMed32319572

2020

TMSB10 acts as a biomarker and promotes progression of clear cell renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qiufeng Pan,Gong Cheng,Yuenan Liu,Tianbo Xu,Hao Zhang,Bing Li

Experimental and therapeutic medicine 18:3759-3766 PubMed31616507

2019

Overexpression of thymosin β10 correlates with disease progression and poor prognosis in bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Bingwei Wang,Zhenwei Wang,Tao Zhang,Guosheng Yang

Stem cell research & therapy 9:166 PubMed29921287

2018

Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Zhang,Wenhui Chu,Qingxiu Liu,Dawn Coates,Yudong Shang,Chunyi Li

BioMed research international 2015:731938 PubMed26339636

2015

Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts.

Applications

Species

Unspecified reactive species

Shiva Marthandan,Steffen Priebe,Mario Baumgart,Marco Groth,Alessandro Cellerino,Reinhard Guthke,Peter Hemmerich,Stephan Diekmann

Molecular & cellular proteomics : MCP 10:M110.005991 PubMed21149303

2010

Revisiting rat spermatogenesis with MALDI imaging at 20-microm resolution.

Applications

IHC-P

Species

Rat

Mélanie Lagarrigue,Michael Becker,Régis Lavigne,Sören-Oliver Deininger,Axel Walch,Florence Aubry,Detlev Suckau,Charles Pineau

Ophthalmic research 41:36-43 PubMed18854659

2008

Overexpression of thymosin beta-10 inhibits VEGF mRNA expression, autocrine VEGF protein production, and tube formation in hypoxia-induced monkey choroid-retinal endothelial cells.

Applications

Species

Human

Tonghe Zhang,Xiaoxin Li,Wenzhen Yu,Zheng Yan,He Zou,Xiangjun He

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Thymosin beta 10 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (7)

Product promise