AB167650

Anti-Thymosin beta 4 antibody

Name: Anti-Thymosin beta 4 antibody (ab167650) | Abcam
Brand: Abcam Limited
SKU: AB167650

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(7 Publications)

Mouse Polyclonal Thymosin beta 4 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TMSB4X.

View Alternative Names

TB4X, THYB4, TMSB4, TMSB4X, Thymosin beta-4, T beta-4, Fx

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-Thymosin beta 4 antibody (AB167650)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Thymosin beta 4 antibody (AB167650)

Immunofluorescent analysis of HeLa cells labeling Thymosin beta 4 with ab167650 at 10 µg/ml.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TMSB4X.

P62328

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Thymosin beta 4 is a small actin-binding peptide known for its role in the regulation of actin polymerization and depolymerization. Sometimes called Tβ4 or beta thymosin this peptide has a mass of approximately 5 kDa. It is widely expressed in various tissues especially in wound sites circulatory system and the central nervous system. The peptide consists of 43 amino acids and its structure allows it to sequester actin monomers influencing the cytoskeleton dynamics within cells.

Biological function summary

Thymosin beta 4 influences several cellular processes including cell migration proliferation and differentiation. It is not part of a large complex but directly interacts with actin to modulate its behavior. Through its regulation of actin filament formation it plays a significant role in wound healing tissue regeneration and inflammatory responses. Furthermore it contributes to the migration of endothelial cells highlighting its importance in angiogenesis.

Pathways

Thymosin beta 4 contributes significantly to cell motility and the vascular endothelial growth factor (VEGF) pathway. It interacts with the protein profilin in the regulation of actin dynamics impacting cellular processes like cell movement and angiogenesis. By influencing these pathways Thymosin beta 4 aids in the body's repair mechanisms providing cellular structural support under varying physiological conditions.

Thymosin beta 4 is associated with cardiovascular diseases and fibrotic disorders. It has a potential protective effect in ischemic heart disease where it contributes to heart repair by modulating actin and promoting endothelial cell migration. In fibrosis its regulatory effects on actin filaments may impact the excessive tissue scarring. Thymosin beta 4 also interacts with proteins like beta-adrenoreceptors during cardiovascular stress responses demonstrating its multi-faceted role in health and disease.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays an important role in the organization of the cytoskeleton (PubMed : 10848969, PubMed : 1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed : 10848969, PubMed : 1999398).. Hemoregulatory peptide AcSDKP. Potent inhibitor of bone marrow derived stem cell differentiation (PubMed : 7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).

See full target information TMSB4X

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Nature cardiovascular research 3:283-300 PubMed38510108

2024

YAP induces a neonatal-like pro-renewal niche in the adult heart.

Applications

Unspecified application

Species

Unspecified reactive species

Rich Gang Li,Xiao Li,Yuka Morikawa,Francisco J Grisanti-Canozo,Fansen Meng,Chang-Ru Tsai,Yi Zhao,Lin Liu,Jong Kim,Bing Xie,Elzbieta Klysik,Shijie Liu,Md Abul Hassan Samee,James F Martin

Cardiovascular therapeutics 2022:1308651 PubMed35712678

2022

Thymosin 4 Protects against Cardiac Damage and Subsequent Cardiac Fibrosis in Mice with Myocardial Infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Wang,Yajuan He,Naijuan Yao,Litao Ruan,Zhen Tian

Bioengineered 12:7104-7118 PubMed34546850

2021

Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Sun,Yan Wei,Junli Wang

Inflammation 45:59-73 PubMed34414534

2021

Thymosin β4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Tian,Naijuan Yao,Fei Wang,Litao Ruan

Journal of neuroinflammation 18:146 PubMed34183019

2021

Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Wang,Li-Rong Feng,Zi-Long Li,Kai-Ge Ma,Ke-Wei Chang,Xin-Lin Chen,Peng-Bo Yang,Sheng-Feng Ji,Yan-Bing Ma,Hua Han,John Bosco Ruganzua,Wei-Na Yang,Yi-Hua Qian

Frontiers in cell and developmental biology 9:684819 PubMed34222253

2021

Cytoplasmic Localization Isoform of Cyclin Y Enhanced the Metastatic Ability of Lung Cancer Regulating Tropomyosin 4.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoting Zhao,Mei Jiang,Yu Teng,Jie Li,Zhefeng Li,Wende Hao,Hongyu Zhao,Chenghong Yin,Wentao Yue

International immunopharmacology 82:106354 PubMed32143008

2020

5-HTR alleviates Aβ-induced cognitive decline and neuroinflammation through crosstalk with NF-κB pathway in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Wang,Hang-Fan Zong,Ke-Wei Chang,Hua Han,Mohammad Yasir Rizvi,Saema Iffat Neha,Zhi-Yi Li,Wei-Na Yang,Yi-Hua Qian

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Thymosin beta 4 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Thymosin beta 4 antibody (AB167650)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (7)

Product promise