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AB12500

Anti-Thyroid Peroxidase/TPO antibody [MoAb47]

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(3 Publications)

Mouse Monoclonal Thyroid Peroxidase/TPO antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human Thyroid peroxidase.

View Alternative Names

Thyroid peroxidase, TPO

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Peroxidase/TPO antibody [MoAb47] (AB12500)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Peroxidase/TPO antibody [MoAb47] (AB12500)

Formalin-fixed, paraffin-embeded human thyroid tissue stained for Thyroid Peroxidase/TPO using ab12500 at 1/10 dilution in immunohistochemical analysis.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MoAb47

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Native Full Length Protein corresponding to Human Thyroid peroxidase.

P07202

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/25", "IHCP-species-notes": "<p>Primary incubation for 30 min at room temperature.</p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }
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AB277455

Human Thyroid Peroxidase/TPO ELISA Kit

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View product

We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.3 - 7.5 Preservative: 0.05% Sodium azide Constituents: Tissue culture supernatant
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Thyroid Peroxidase (TPO) also known as thyroperoxidase is an enzyme with a molecular mass of around 105 kDa. It is expressed in the thyroid gland's follicular cells. TPO plays a mechanical role in the synthesis of thyroid hormones by catalyzing iodination and coupling reactions needed to produce triiodothyronine (T3) and thyroxine (T4). These hormones are essential for regulating metabolism growth and development. The activity of TPO is an important step in thyroid hormone production.
Biological function summary

TPO participates in the thyroid's hormone biosynthesis pathway. It forms a part of the multi-enzyme complex that includes thyroglobulin and iodide. The enzyme facilitates the iodination of tyrosine residues on thyroglobulin and the coupling of iodotyrosines important for creating active thyroid hormones. TPO's enzymatic function is important for maintaining appropriate levels of circulating T3 and T4 impacting various physiological processes in the body.

Pathways

TPO contributes to the thyroid hormone synthesis pathway which is a critical pathway for metabolic regulation. It works in close association with other proteins such as thyroglobulin and sodium/iodide symporter (NIS) to ensure efficient thyroid hormone production. TPO's involvement in these pathways indicates its importance in the endocrine system's normal function and homeostasis.

TPO is often associated with autoimmune thyroid diseases like Hashimoto's thyroiditis and Graves' disease. High TPO antibodies such as anti-TPO antibodies are commonly detected in these conditions indicating an autoimmune response against the thyroid. The presence of high anti-thyroid peroxidase antibodies can lead to the destruction of thyroid tissue often resulting in hypothyroidism. TPO's connection to these diseases highlights its role in autoimmune conditions affecting thyroid function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
See full target information Thyroid peroxidase
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of cancer 134:1706-14 PubMed24114667

2013

Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer?

Applications

Unspecified application

Species

Unspecified reactive species

I Muller,C Giani,L Zhang,F A Grennan-Jones,E Fiore,V Belardi,V Rosellini,N Funel,D Campani,E Giustarini,M D Lewis,A D Bakhsh,M Roncella,M Ghilli,P Vitti,C M Dayan,M E Ludgate

Biochemical and biophysical research communications 392:22-8 PubMed20043873

2010

Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destruction.

Applications

Unspecified application

Species

Unspecified reactive species

Dana M Cairns,Tomoya Uchimura,Heenam Kwon,Philip G Lee,Christopher R Seufert,Elizabeth Matzkin,Li Zeng

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 28:529-36 PubMed19813241

2009

The role of muscle cells in regulating cartilage matrix production.

Applications

Unspecified application

Species

Unspecified reactive species

Dana M Cairns,Philip G Lee,Tomoya Uchimura,Christopher R Seufert,Heenam Kwon,Li Zeng
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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