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AB216601

Anti-Thyrotropin Releasing Hormone (TRH) antibody

3

(1 Review)

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(1 Publication)

Rabbit Polyclonal Thyrotropin Releasing Hormone (TRH) antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TRH conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Pro-thyrotropin-releasing hormone, Pro-TRH, Prothyroliberin, TRH, TRF, TRH, Protirelin, Thyroliberin, Prothyroliberin, TSH releasing factor, Thyroliberin [Precursor], Thyrotropin releasing factor, Thyrotropin-releasing hormone

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyrotropin Releasing Hormone (TRH) antibody (AB216601)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyrotropin Releasing Hormone (TRH) antibody (AB216601)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of Human colon cancer tissue labeling Thyrotropin Releasing Hormone (TRH) with ab216601 at a 1/200 dilution, followed by conjugation to a secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TRH conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P20396

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Thyrotropin Releasing Hormone (TRH) also known as thyroliberin is a tripeptide hormone with a molecular mass of approximately 362.4 Da. This hormone mainly expresses in the hypothalamus of the brain. TRH plays an important role in the regulation of the thyroid axis by stimulating the secretion of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. Additionally it influences the release of prolactin another pituitary hormone.
Biological function summary

TRH serves important regulatory functions within the endocrine system. Notably TRH is an initiator in the hypothalamic-pituitary-thyroid (HPT) axis. It does not form part of a larger complex but acts as a standalone signaling molecule. This hormone facilitates communication between the central nervous system and the endocrine system influencing metabolic processes and affecting growth and development via its role in TSH and prolactin secretion.

Pathways

TRH activates specific cell surface receptors linked to G-protein coupled signaling which increases the production of intracellular second messengers such as inositol triphosphate (IP3) and calcium ions. One significant pathway is the HPT axis which integrates TRH into a feedback cycle with thyroid hormones like thyroxine (T4) and triiodothyronine (T3). Proteins related to TRH within this signaling pathway include its target TSH which in turn regulates the biosynthesis of T3 and T4 in the thyroid gland.

TRH has been implicated in conditions such as hypothyroidism and major depressive disorder. In hypothyroidism insufficient production of TRH can result in decreased levels of TSH leading to reduced production of thyroid hormones and subsequent metabolic dysregulation. In major depressive disorder alterations in the HPT axis involving TRH may affect mood and cause other psychiatric symptoms. The function of TRH in these disorders highlights its interconnectedness with both TSH and the broader hormonal regulation within the body.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.
See full target information TRH
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of comparative neurology 531:1017-1031 PubMed37121600

2023

Uncovering the brain-wide pattern of synaptic input to vasopressin-expressing neurons in the paraventricular nucleus of the hypothalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan Woodson,Joseph F Bergan
View all publications
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Product promise

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