Anti-Thyroxine antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Thyroxine plays an important role in regulating metabolism and growth rate across numerous cell types. It influences a wide range of processes including energy production and consumption thermoregulation and protein synthesis. In cellular contexts thyroxine does not form part of any complex. Instead it freely crosses cell membranes and binds directly to nuclear receptors primarily the thyroid hormone receptor which modifies gene transcription within target cells.

Pathways

Thyroxine has central involvement in the hypothalamus-pituitary-thyroid (HPT) axis and metabolic pathway regulation. Through the HPT axis thyroxine influences the release of thyrotropin-releasing hormone and thyroid-stimulating hormone maintaining hormonal balance in the body. In the metabolic pathway thyroxine links with proteins like peroxisome proliferator-activated receptors which oversee lipid metabolism. Its interaction aids in the conversion of macromolecules serving a critical role in daily cellular function.