Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Product Insider Program
Be the first to know about our latest product launches - and unlock exclusive offers and discounts.
Rabbit Polyclonal TIAM1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TIAM1 aa 1450-1550 conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | WB | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100 | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/1000 | Notes - |
Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.
Rho guanine nucleotide exchange factor TIAM1, T-lymphoma invasion and metastasis-inducing protein 1, TIAM-1, TIAM1
Rabbit Polyclonal TIAM1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TIAM1 aa 1450-1550 conjugated to Keyhole Limpet Haemocyanin.
Rho guanine nucleotide exchange factor TIAM1, T-lymphoma invasion and metastasis-inducing protein 1, TIAM-1, TIAM1
IgG
Rabbit
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
TIAM1 influences several cellular processes such as cell polarity migration and growth. It forms a complex with several other proteins and plays a role in reorganizing the actin cytoskeleton. This ability to modulate the cytoskeleton impacts the cell's ability to move and change shape which are essential during developmental processes and in maintaining tissue architecture. TIAM1 also affects cell-cell adhesion through interactions with E-cadherin which suggests its involvement in stabilizing cellular contacts.
TIAM1 also known as T-cell lymphoma invasion and metastasis 1 is a significant regulator in cellular dynamics. It functions as a guanine nucleotide exchange factor (GEF) predominantly for the Rho family of GTPases particularly Rac1. With a mass of approximately 188 kDa TIAM1 is ubiquitously expressed in various tissues indicating its broad role in cellular activities. The protein modulates cytoskeletal organization and cell-migration by exchanging GDP for GTP on Rac1 therefore activating it.
The role of TIAM1 can be observed prominently in the Wnt and PI3K/Akt signaling pathways. In the Wnt pathway TIAM1 interacts with the β-catenin pathway influencing processes like gene expression cell behavior and differentiation. It co-localizes with Dsh and APC influencing the signaling cascade that controls cell fate decisions. In the PI3K/Akt pathway it impacts cell survival and metabolism showing TIAM1's engagement with multiple proteins like PI3K and Akt which further affects cell proliferation and survival mechanisms.
TIAM1 shows a significant connection to cancer and neurological disorders. Its role in promoting cancer cell invasion and metastasis is evident in various tumor types where altered TIAM1 expression correlates with tumor progression and poor prognosis. In cancer it engages with proteins such as MMPs facilitating extracellular matrix degradation and metastasis. Furthermore aberrant TIAM1 expression or dysfunction is associated with some neurological disorders indicating its possible involvement in neurodevelopmental or neurodegenerative conditions where related proteins like Rac1 play an important part.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon tissue labeling TIAM1 with ab211518 at 1/100 dilution.
All lanes: Western blot - Anti-TIAM1 antibody (AB211518) at 1/1000 dilution
All lanes: ZR-75-1 cell line lysates at 35 µg
Predicted band size: 178 kDa
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com