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AB103578

Anti-TIAM2 antibody

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(1 Publication)

Rabbit Polyclonal TIAM2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TIAM2.

View Alternative Names

KIAA2016, STEF, TIAM2, Rho guanine nucleotide exchange factor TIAM2, SIF and TIAM1-like exchange factor, T-lymphoma invasion and metastasis-inducing protein 2, TIAM-2

2 Images
Western blot - Anti-TIAM2 antibody (AB103578)
  • WB

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Western blot - Anti-TIAM2 antibody (AB103578)

All lanes:

Western blot - Anti-TIAM2 antibody (ab103578) at 5 µg/mL

All lanes:

K562 cell lysate at 50 µg

Predicted band size: 71 kDa

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Western blot - Anti-TIAM2 antibody (AB103578)
  • WB

Unknown

Western blot - Anti-TIAM2 antibody (AB103578)

All lanes:

Western blot - Anti-TIAM2 antibody (ab103578) at 5 µg/mL

Lane 1:

TIAM2 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Predicted band size: 71 kDa

Observed band size: 80 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TIAM2.

Q8IVF5

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: 100% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TIAM2 also known as T-cell lymphoma invasion and metastasis 2 is a guanine nucleotide exchange factor (GEF) with a mass of approximately 180 kDa. It plays a significant role mechanically by activating the small GTPase Rac1 leading to changes in actin cytoskeleton organization. This protein localizes in the cytoplasm and shows expression in many tissues but finds higher levels in the brain and lymphoid organs. Its role extends to cellular processes like cell migration proliferation and adhesion.
Biological function summary

TIAM2 contributes to intracellular signaling that governs cell shape and movement. It participates as part of a larger signaling complex that includes other GEFs and scaffold proteins. By facilitating the switch of Rac1 from inactive GDP-bound state to active GTP-bound state TIAM2 influences pathways that control the dynamics of the actin cytoskeleton important for cellular structural change highlighting its importance in the development of cellular architecture and motility.

Pathways

TIAM2 activates signaling cascades related to cell migration and differentiation. It plays an essential role in the Rac1-PAK pathway which regulates the actin cytoskeleton dynamics. This pathway interconnects with other signaling molecules like CDC42 and PAK kinases creating a network that controls cellular responses and contacts with the extracellular matrix. In this network TIAM2 acts as a facilitator for cellular adaptation to environmental stimuli.

TIAM2 links to conditions such as cancer metastasis and neurological disorders. Alterations in its expression or function contribute to the progression of certain cancers by promoting increased motility and invasive capabilities of tumor cells. Additionally abnormalities in TIAM2 activity have been observed in diseases like schizophrenia where it interacts with proteins such as DISC1 affecting neuronal signaling and stability. Understanding TIAM2's involvement in these diseases provides insight into therapeutic targets for managing disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
See full target information TIAM2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e23242 PubMed37801065

2023

TIAM2S-positive microglia enhance inflammation and neurotoxicity through soluble ICAM-1-mediated immune priming.

Applications

Unspecified application

Species

Unspecified reactive species

Chun-Hsien Chu,Jia-Shing Chen,Ya-Ling Chan,Wei-Jen Lu,Yi-Te Huang,Pin-Cheng Mao,Chun-I Sze,H Sunny Sun
View all publications
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Product promise

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