Anti-Tim 2 antibody [RMT2-14]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

T-cell immunoglobulin and mucin domain 2 (Tim-2) also known as HAVCR2 is a protein with a molecular mass of approximately 80 kDa. Tim-2 expresses mainly in the immune system particularly in T cells B cells and dendritic cells. It acts as a receptor with a potential role in regulating the immune response. Tim-2 also presents in various tissues including the liver and kidney suggesting its involvement in multiple physiological processes.

Biological function summary

Tim-2 plays an important role in immune regulation and functions as a part of the broader family of T-cell immunoglobulin and mucin domain proteins. It does not typically form part of a complex but interacts with phosphatidylserine a phospholipid exposed during cell apoptosis. This interaction suggests Tim-2 has roles in recognizing apoptotic cells and may influence their removal by macrophages. Additionally it affects lymphocyte activity possibly by modulating T-cell proliferation and cytokine release.

Pathways

Tim-2 influences immune responses and cell survival pathways. It connects to the phosphatidylserine-mediated clearance pathway a critical component of maintaining tissue homeostasis and preventing inflammation by promoting the clearance of dying cells. Tim-2 also interacts with related proteins such as Tim-3 which shares similar ligand-binding properties and roles in immune response modulation.

Associated diseases and disorders

Tim-2 relates to its role in immune system regulation and its connection to inflammatory disorders and autoimmune diseases. It is implicated in conditions like multiple sclerosis and asthma. In multiple sclerosis Tim-2 and Tim-3 can influence the immune tolerance and inflammation rate affecting disease progression. These connections highlight Tim-2 as a potential target for therapeutic interventions in autoimmune and inflammatory diseases.