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AB281910

Anti-Tim 2 antibody [RMT2-14] - Rabbit IgG (Chimeric)

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(1 Publication)

Rabbit Recombinant Monoclonal Tim 2 antibody. Suitable for ICC/IF and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Mouse Timd2 aa 1-250.

View Alternative Names

Tim2, Timd2, T-cell immunoglobulin and mucin domain-containing protein 2, TIMD-2, T-cell immunoglobulin mucin receptor 2, T-cell membrane protein 2, TIM-2

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Tim 2 antibody [RMT2-14] - Rabbit IgG (Chimeric) (AB281910)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Tim 2 antibody [RMT2-14] - Rabbit IgG (Chimeric) (AB281910)

Immunofluorescence analysis of paraformaldehyde fixed mouse splenocytes on Shi-fix® coverslips stained with the chimeric ab281910 at 10 μg/ml for 1 hour, followed by Alexa Fluor® 488 secondary antibody at 2 μg/ml (green/top-left). Image showing membrane staining. The nuclear counter stain is DAPI (blue). The isotype control was an unknown specificity antibody followed by staining with Alexa Fluor® 488 secondary antibody. Mouse splenocytes were immobilized on Shi-fix® coverslips.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

RMT2-14

Isotype

IgG

Light chain type

lambda

Carrier free

No

Reacts with

Mouse

Applications

ICC/IF

applications

Immunogen

Recombinant Protein within Mouse Timd2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q8R183

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Product details

ab281910 is the chimeric rabbit version of ab281909.

This rabbit monoclonal chimeric antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.02% Proclin 300 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

T-cell immunoglobulin and mucin domain 2 (Tim-2) also known as HAVCR2 is a protein with a molecular mass of approximately 80 kDa. Tim-2 expresses mainly in the immune system particularly in T cells B cells and dendritic cells. It acts as a receptor with a potential role in regulating the immune response. Tim-2 also presents in various tissues including the liver and kidney suggesting its involvement in multiple physiological processes.
Biological function summary

Tim-2 plays an important role in immune regulation and functions as a part of the broader family of T-cell immunoglobulin and mucin domain proteins. It does not typically form part of a complex but interacts with phosphatidylserine a phospholipid exposed during cell apoptosis. This interaction suggests Tim-2 has roles in recognizing apoptotic cells and may influence their removal by macrophages. Additionally it affects lymphocyte activity possibly by modulating T-cell proliferation and cytokine release.

Pathways

Tim-2 influences immune responses and cell survival pathways. It connects to the phosphatidylserine-mediated clearance pathway a critical component of maintaining tissue homeostasis and preventing inflammation by promoting the clearance of dying cells. Tim-2 also interacts with related proteins such as Tim-3 which shares similar ligand-binding properties and roles in immune response modulation.

Tim-2 relates to its role in immune system regulation and its connection to inflammatory disorders and autoimmune diseases. It is implicated in conditions like multiple sclerosis and asthma. In multiple sclerosis Tim-2 and Tim-3 can influence the immune tolerance and inflammation rate affecting disease progression. These connections highlight Tim-2 as a potential target for therapeutic interventions in autoimmune and inflammatory diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed : 16203866, PubMed : 33065090). Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed : 16043519, PubMed : 21886823). Plays also an important role in the regulation of Th2 immunity (PubMed : 16043519). Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed : 12374982).
See full target information Timd2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 32: PubMed40539438

2025

circRNA hsa_circ_0072107 aggravates myocardial hypertrophy via its function as a competitive endogenous RNA of miR‑516b‑5p.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Wang,Yongli He,Wuxia Ma,Jindong Xu,Qi Zhong,Cheng Huang
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Product promise

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