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AB126044

Anti-TIMM17A/TIM17 antibody

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(2 Reviews)

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(1 Publication)

Rabbit Polyclonal TIMM17A/TIM17 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TIMM17A aa 1-150.
2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM17A/TIM17 antibody (AB126044)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM17A/TIM17 antibody (AB126044)

ab126044 at 1/500 dilution, staining TIMM17A/TIM17 in Formalin-fixed Paraffin-embedded Human CL15 xenograft tissue by Immunohistochemistry.

Western blot - Anti-TIMM17A/TIM17 antibody (AB126044)
  • WB

Unknown

Western blot - Anti-TIMM17A/TIM17 antibody (AB126044)

12% SDS PAGE

All lanes:

Western blot - Anti-TIMM17A/TIM17 antibody (ab126044) at 1/1000 dilution

All lanes:

K562 whole cell lysate at 30 µg

Predicted band size: 18 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TIMM17A aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q99595

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Product details

Keep as concentrated solution.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TIMM17A also known as TIM17A or simply TIM17 is a protein component of the mitochondrial inner membrane translocase complex. It is involved in the import of nuclear-encoded proteins into the mitochondria. With a molecular mass of approximately 19 kDa TIMM17A is primarily expressed in the inner mitochondrial membrane. This protein forms part of the TIM23 complex which mediates the translocation of presequence-containing preproteins into the mitochondrial inner membrane or matrix.
Biological function summary

The TIMM17A protein facilitates the import of essential mitochondrial proteins securing proper mitochondrial function and energy production. TIMM17A as part of the TIM23 translocase complex cooperates closely with other TIM proteins such as TIMM50 and TIMM23 to ensure protein import is efficient and targeted. Its role in maintaining mitochondrial integrity also supports cellular metabolism and the regulation of apoptotic processes which are processes responsible for programmed cell death.

Pathways

The TIMM17A protein plays a significant role in the mitochondrial protein import pathway. It interacts with other key proteins like HSP70 and mtHSP70 which manipulate peptide folding and assist in pulling preproteins through the TIM23 channel. The proper import of these proteins is essential for the oxidative phosphorylation pathway which is important for ATP production. This pathway enables ATP synthesis by transferring electrons through a sequence of electron transport chain complexes located in the mitochondrial inner membrane.

Research associates TIMM17A dysfunction with mitochondrial myopathy a disorder characterized by muscle weakness and dysfunction due to impaired mitochondrial performance. Studies also link alterations in TIMM17A to certain neurodegenerative disorders such as Parkinson’s disease where mitochondrial dysfunction plays an important role. The protein's interaction with other import machinery members during these conditions like TIMM44 highlights its importance in maintaining mitochondrial health and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
See full target information TIMM17A

Alternative Names

MIMT17, TIM17, TIM17A, TIMM17, TIMM17A, Mitochondrial import inner membrane translocase subunit Tim17-A, Inner membrane preprotein translocase Tim17a
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cells 11: PubMed35011609

2022

KANPHOS: A Database of Kinase-Associated Neural Protein Phosphorylation in the Brain.

Applications

Unspecified application

Species

Unspecified reactive species

Rijwan Uddin Ahammad,Tomoki Nishioka,Junichiro Yoshimoto,Takayuki Kannon,Mutsuki Amano,Yasuhiro Funahashi,Daisuke Tsuboi,Md Omar Faruk,Yukie Yamahashi,Kiyofumi Yamada,Taku Nagai,Kozo Kaibuchi
View all publications
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Product promise

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