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AB122034

Anti-TIMM17B antibody

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Rabbit Polyclonal TIMM17B antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TIMM17B aa 100 to C-terminus.

View Alternative Names

TIM17B, JM3, TIMM17B, Mitochondrial import inner membrane translocase subunit Tim17-B

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM17B antibody (AB122034)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM17B antibody (AB122034)

ab122034 at 1/85 dilution staining TIMM17B in paraffin-embedded Human duodenum tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM17B antibody (AB122034)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM17B antibody (AB122034)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placenta tissue labelling TIMM17B with ab122034 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM17B antibody (AB122034)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM17B antibody (AB122034)

ab122034 at 1/85 dilution staining TIMM17B in paraffin-embedded Human kidney tissue by Immunohistochemistry.

Western blot - Anti-TIMM17B antibody (AB122034)
  • WB

Supplier Data

Western blot - Anti-TIMM17B antibody (AB122034)

All lanes:

Western blot - Anti-TIMM17B antibody (ab122034) at 0.4 µg/mL

Lane 1:

RT4 (human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG (formally U-373 MG) (human brain glioma cell line) cell lysate

Predicted band size: 18 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TIMM17B aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O60830

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TIMM17B also known as Translocase of Inner Mitochondrial Membrane 17 homolog B is a protein component with a molecular mass of approximately 21 kDa. TIMM17B is importantly involved in the translocation of proteins across the mitochondrial inner membrane. This protein is expressed in various tissues but shows higher expression in testis and heart. TIMM17B plays a critical role in mitochondrial function by acting as a channel-forming protein within the TIMM complex.
Biological function summary

TIMM17B integrates its function into the import machinery for mitochondrial proteins. It is part of the TIM22 complex an important multi-protein system that mediates the insertion and assembly of certain hydrophobic proteins into the mitochondrial inner membrane. TIMM17B works in coordination with other TIMM proteins such as TIM22 to facilitate the transfer and integration of mitochondrial carrier proteins. This integration supports the effective maintenance of mitochondrial functions which are essential for cellular energy metabolism.

Pathways

TIMM17B plays a significant role in the mitochondrial protein import pathway. This process involves the transport of proteins synthesized in the cytosol into the mitochondria which is essential for mitochondrial biogenesis and function. TIMM17B is also linked with the oxidative phosphorylation pathway through its involvement in maintaining mitochondrial membrane potential. Proteins like TIMM23 and TIMM50 are closely related to TIMM17B within these pathways providing important support for its function in importing proteins necessary for energy production.

TIMM17B has been connected to mitochondrial disorders and neurodegenerative diseases. Disturbances in its function or expression can affect mitochondrial integrity contributing to conditions such as Leigh syndrome. Moreover TIMM17B shows associations with Alzheimer's disease where defects in mitochondrial dynamics and energy metabolism play a role. These connections also involve the protein PINK1 which is associated with autosomal recessive early-onset Parkinson's disease highlighting the importance of mitochondrial quality control in neurodegenerative disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
See full target information TIMM17B
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Product promise

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