AB238738

Anti-TIMM8B antibody

Name: Anti-TIMM8B antibody (ab238738) | Abcam
Brand: Abcam Limited
SKU: AB238738

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(1 Publication)

Rabbit Polyclonal TIMM8B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TIMM8B aa 1 to C-terminus.

View Alternative Names

DDP2, DDPL, TIM8B, TIMM8B, Mitochondrial import inner membrane translocase subunit Tim8 B, DDP-like protein, Deafness dystonia protein 2

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM8B antibody (AB238738)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM8B antibody (AB238738)

Paraffin-embedded human adrenal gland tissue stained for TIMM8B using ab238738 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TIMM8B aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5J9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity greater than 95%.

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TIMM8B also known as Deafness Dystonia Protein 2 (DDP2) is a small protein with a molecular mass of about 10 kDa. It is expressed mainly in the mitochondria and is part of the intermembrane space machinery. TIMM8B plays a mechanical role in the mitochondrial protein translocase system helping transport specific proteins from the cytosol into the mitochondrial intermembrane space. The protein is part of a family that includes TIMM8A and it operates as a subunit of a larger assembly that aids in correct protein localization within the mitochondria.

Biological function summary

TIMM8B contributes to cellular energy regulation by ensuring the proper functioning of the mitochondrial protein import machinery. TIMM8B forms a complex with TIMM13 another mitochondrial intermembrane space assembly. This complex assists in the import and insertion of essential proteins across the mitochondrial membranes which is important for mitochondrial respiratory chain and energy metabolism. Disruptions in this complex can impair mitochondrial function and cellular energy dynamics.

Pathways

The mitochondria rely heavily on the TIMM8B-TIMM13 complex during the translocation process which influences the oxidative phosphorylation pathway. The complex components coordinate with the mitochondrial inner membrane translocase TIMM23 to ensure efficient energy production. Furthermore TIMM8B interacts indirectly with proteins such as cytochrome c as part of the electron transport chain highlighting its role in maintaining mitochondrial integrity and activity.

TIMM8B mutations or dysfunctions have been associated with auditory and neurological conditions such as Mohr-Tranebjaerg syndrome and possibly Charcot-Marie-Tooth disease. These diseases illustrate the protein's significance in sensory and nervous system function. TIMM8B may influence these diseases through its association with TIMM8A which has well-documented connections to similar auditory and neurological impairments. Understanding TIMM8B's function in mitochondrial protein import pathways can provide insights into the molecular bases of these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).

See full target information TIMM8B

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Bioengineered 12:5323-5333 PubMed34499008

2021

The tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients.

Applications

Unspecified application

Species

Unspecified reactive species

Wenfa Yi,Yong Yu,Yafei Li,Juan Yang,Shuying Gao,Lingfen Xu

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-TIMM8B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM8B antibody (AB238738)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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