Rabbit Polyclonal TIMM8B antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TIMM8B aa 1 to C-terminus.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human TIMM8B aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y5J9
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Cow | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/200.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Target data
Function
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
Alternative names
DDP2, DDPL, TIM8B, TIMM8B, Mitochondrial import inner membrane translocase subunit Tim8 B, DDP-like protein, Deafness dystonia protein 2
Recommended products
Rabbit Polyclonal TIMM8B antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TIMM8B aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human TIMM8B aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y5J9
- Purification technique
- Affinity purification Protein G
- Concentration
- Purification notes
Purity greater than 95%.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TIMM8B also known as Deafness Dystonia Protein 2 (DDP2) is a small protein with a molecular mass of about 10 kDa. It is expressed mainly in the mitochondria and is part of the intermembrane space machinery. TIMM8B plays a mechanical role in the mitochondrial protein translocase system helping transport specific proteins from the cytosol into the mitochondrial intermembrane space. The protein is part of a family that includes TIMM8A and it operates as a subunit of a larger assembly that aids in correct protein localization within the mitochondria.
- Biological function summary
TIMM8B contributes to cellular energy regulation by ensuring the proper functioning of the mitochondrial protein import machinery. TIMM8B forms a complex with TIMM13 another mitochondrial intermembrane space assembly. This complex assists in the import and insertion of essential proteins across the mitochondrial membranes which is important for mitochondrial respiratory chain and energy metabolism. Disruptions in this complex can impair mitochondrial function and cellular energy dynamics.
- Pathways
The mitochondria rely heavily on the TIMM8B-TIMM13 complex during the translocation process which influences the oxidative phosphorylation pathway. The complex components coordinate with the mitochondrial inner membrane translocase TIMM23 to ensure efficient energy production. Furthermore TIMM8B interacts indirectly with proteins such as cytochrome c as part of the electron transport chain highlighting its role in maintaining mitochondrial integrity and activity.
- Associated diseases and disorders
TIMM8B mutations or dysfunctions have been associated with auditory and neurological conditions such as Mohr-Tranebjaerg syndrome and possibly Charcot-Marie-Tooth disease. These diseases illustrate the protein's significance in sensory and nervous system function. TIMM8B may influence these diseases through its association with TIMM8A which has well-documented connections to similar auditory and neurological impairments. Understanding TIMM8B's function in mitochondrial protein import pathways can provide insights into the molecular bases of these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMM8B antibody (ab238738)
Paraffin-embedded human adrenal gland tissue stained for TIMM8B using ab238738 at 1/100 dilution in immunohistochemical analysis.
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