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AB171949

Anti-TIMMDC1/C3orf1 antibody [EPR11808]

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Rabbit Recombinant Monoclonal TIMMDC1/C3orf1 antibody. Suitable for WB and reacts with Human samples.

View Alternative Names

C3orf1, UNQ247/PRO284, TIMMDC1, Protein M5-14, Translocase of inner mitochondrial membrane domain-containing protein 1, TIMM domain containing-protein 1

1 Images
Western blot - Anti-TIMMDC1/C3orf1 antibody [EPR11808] (AB171949)
  • WB

Supplier Data

Western blot - Anti-TIMMDC1/C3orf1 antibody [EPR11808] (AB171949)

All lanes:

Western blot - Anti-TIMMDC1/C3orf1 antibody [EPR11808] (ab171949) at 1/1000 dilution

Lane 1:

A375 cell lysate at 10 µg

Lane 2:

THP-1 cell lysate at 10 µg

Lane 3:

Jurkat cell lysate at 10 µg

Lane 4:

A673 cell lysate at 10 µg

Lane 5:

Human fetal heart cell lysate at 10 µg

Lane 6:

Human fetal muscle lysate at 10 µg

Predicted band size: 32 kDa

false

  • Carrier free

    Anti-TIMMDC1/C3orf1 antibody [EPR11808] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11808

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TIMMDC1 also known as C3orf1 is a mitochondrial protein with a mass of approximately 34 kDa. It plays a mechanical role in the assembly of mitochondrial respiratory chain complex I. It becomes integrated into the inner mitochondrial membrane where it acts as an important assembly factor. TIMMDC1 is expressed ubiquitously across various human tissues with relatively higher levels in tissues with high energy demands like the heart and skeletal muscle.
Biological function summary

TIMMDC1 is essential in maintaining cellular energy metabolism. It is a component of the mitochondrial complex I assembly pathway critical for the formation and stabilization of the entire complex I. Complex I is responsible for the initial steps of the electron transport chain important for ATP production via oxidative phosphorylation. TIMMDC1 interacts with other complex I assembly factors contributing to the efficient generation of ATP within mitochondria.

Pathways

TIMMDC1 has a significant impact on the oxidative phosphorylation pathway and is a pivotal part of the mitochondrial respiratory chain. Its activity influences cellular respiration by assisting the functional integrity of complex I which interacts closely with other oxidative phosphorylation participants such as NADH dehydrogenase (ubiquinone) and cytochrome c oxidase. TIMMDC1 plays its role alongside these proteins facilitating the production of energy that cells require for various metabolic processes.

Defects in TIMMDC1 have been linked to mitochondrial complex I deficiency a condition that can result in a spectrum of disorders such as Leigh syndrome and other encephalomyopathies. This protein's malfunction can disrupt normal energy production leading to energy deficits in cells particularly in the nervous system and muscles. Additionally disruptions in the TIMMDC1 protein interaction with other mitochondrial proteins can exacerbate disease phenotypes such as with NDUFAF3 another mitochondrial assembly factor associated with complex I deficiency.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chaperone protein involved in the assembly of the mitochondrial NADH : ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I.
See full target information TIMMDC1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB171978

Anti-TIMMDC1/C3orf1 antibody [EPR11807]

primary-antibodies

timmdc1-c3orf1-antibody-epr11807-ab171978

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