JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB216432

Anti-TIMP1 antibody

4

(1 Review)

|

(9 Publications)

Rabbit Polyclonal TIMP1 antibody. Suitable for IHC-P and reacts with Human, Mouse samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human TIMP1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CLGI, TIMP, TIMP1, Metalloproteinase inhibitor 1, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, EPA, Collagenase inhibitor, TIMP-1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP1 antibody (AB216432)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP1 antibody (AB216432)

Immunohistochemical analysis of formalin fixed paraffin-embedded human colon carcinoma tissue sections labeling TIMP1 with ab216432 at a 1/200 dilution. DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TIMP1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P01033

style
left-column

Alternative Products

Primary Antibodies

AB211926

Anti-TIMP1 antibody [EPR18352]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP1 antibody [EPR18352] (AB211926)

  • 5
  • 10
Primary Antibodies

AB179580

Anti-TIMP1 antibody [EPR16616]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-TIMP1 antibody [EPR16616] (AB179580)

  • 0
  • 0
Primary Antibodies

AB240504

Anti-TIMP1 antibody [EPR1550] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP1 antibody [EPR1550] - BSA and Azide free (AB240504)

  • 0
  • 0
Primary Antibodies

AB219471

Anti-TIMP1 antibody [EPR18352] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP1 antibody [EPR18352] - BSA and Azide free (AB219471)

  • 0
  • 0
Primary Antibodies

AB232937

Anti-TIMP1 antibody [EPR16616] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-TIMP1 antibody [EPR16616] - BSA and Azide free (AB232937)

  • 0
  • 0
Primary Antibodies

AB109125

Anti-TIMP1 antibody [EPR1550]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP1 antibody [EPR1550] (AB109125)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB92536

Anti-MMP2 antibody [EPR1184]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-MMP2 antibody [EPR1184] (AB92536)

  • 4
  • 6
Primary Antibodies

AB283575

Anti-MMP9 antibody [RM1020]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Trial Size

Flow Cytometry (Intracellular) - Anti-MMP9 antibody [RM1020] (AB283575)

  • 0
  • 0
Primary Antibodies

AB1828

Anti-TIMP2 antibody [3A4]

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP2 antibody [3A4] (AB1828)

  • 4
  • 7
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tissue Inhibitor of Metalloproteinase 1 (TIMP1) is a protein with a molecular mass of approximately 28 kDa. The protein inhibits metalloproteinases by binding to them preventing the breakdown of the extracellular matrix. This action regulates extracellular environment and tissue remodeling. TIMP1 is also known by the name Erythroid-Potentiating Activity (EPA). It is expressed in various tissues including the liver and the brain and can be found in high levels in the blood serum.
Biological function summary

TIMP1 plays several essential roles beyond inhibiting metalloproteinases. It supports cell proliferation and influences apoptosis. It is part of a larger TIMP family and does not function as part of a complex per se but interacts closely with matrix metalloproteinases (MMPs). By regulating MMP activity TIMP1 balances processes like tissue growth and inflammatory responses which are important for normal development and repair.

Pathways

TIMP1 participates in the regulation of the matrix metalloproteinase pathway impacting tissue homeostasis and repair. It closely associates with proteins such as MMP-9 and MMP-2 within this pathway. TIMP1 also plays a role in cytokine signaling pathways which influence immune responses by interacting with other signaling molecules and receptors that govern these pathways.

TIMP1's regulation of MMPs links it to cancer and cardiovascular disease progression. Overexpression of TIMP1 associates with tumor growth and metastasis where it can modulate interactions with other proteins like MMP-9 leading to altered tissue invasion and angiogenesis. Additionally TIMP1 imbalance connects to tissue fibrosis in cardiovascular disorders working in tandem with proteins such as MMP-2 which affects the structural remodeling and function of tissues within the cardiovascular system.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
See full target information TIMP1
style
left-column

Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Acta biochimica et biophysica Sinica 57:473-485 PubMed39844643

2025

Immunopathological characteristics and therapeutic effects of UC-MSCs in a pigeon breeder's lung mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Jingran Xu,Li Li,Yaping Zhou,Zulipikaer Abudureheman,Lexin Xue,Chao Wu,Xiaoguang Zou

Journal of inflammation research 17:7745-7760 PubMed39494202

2024

Transcriptomic Insights into Hub Genes, Immune Infiltration, and Candidate Drugs in Erosive Esophagitis.

Applications

Unspecified application

Species

Unspecified reactive species

Ye Zhao,Xi Chen,Yuhan Huang,Zhihan Zhang,Kui Wang,Duowu Zou,Teng Ma

Diabetology & metabolic syndrome 16:98 PubMed38715117

2024

miR-449a disturbs atherosclerotic plaque stability in streptozotocin and high-fat diet-induced diabetic mice by targeting CEACAM1.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Yu,Han Liu,Yu Chen,Ling Wang,Peng Chen,Yue Zhao,Chunxia Ou,Wei Chen,Jie Hu,Yu Wang,Yan Wang

Tropical medicine and infectious disease 7: PubMed36355906

2022

Jagged-1/Notch Pathway and Key Transient Markers Involved in Biliary Fibrosis during Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Kovner,Oxana Zaparina,Yaroslav Kapushchak,Galina Minkova,Viatcheslav Mordvinov,Maria Pakharukova

Journal of cardiovascular translational research 16:3-16 PubMed36197585

2022

Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Upendra Chalise,Mediha Becirovic-Agic,Jocelyn R Rodriguez-Paar,Shelby R Konfrst,Sharon D B de Morais,Catherine S Johnson,Elizabeth R Flynn,Michael E Hall,Daniel R Anderson,Leah M Cook,Kristine Y DeLeon-Pennell,Merry L Lindsey

Stem cell research & therapy 13:407 PubMed35941707

2022

Human adipose-derived mesenchymal stem cells-derived exosomes encapsulated in pluronic F127 hydrogel promote wound healing and regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Zhou,Xing-Liao Zhang,Shou-Tao Lu,Ning-Yan Zhang,Hai-Jun Zhang,Jing Zhang,Jun Zhang

Journal of materials science. Materials in medicine 33:12 PubMed35050422

2022

Adipose-derived mesenchymal stem cell-loaded β-chitin nanofiber hydrogel promote wound healing in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Liu,Yunen Liu,Mi Wu,Rufei Zou,Shun Mao,Peifang Cong,Mingxiao Hou,Hongxu Jin,Yan Zhao,Yongli Bao

BMC medical genomics 14:237 PubMed34587952

2021

Identification and validation of pivotal genes related to age-related meniscus degeneration based on gene expression profiling analysis and in vivo and in vitro models detection.

Applications

Unspecified application

Species

Unspecified reactive species

Ming Chen,Siqi Zhou,Huasong Shi,Hanwen Gu,Yinxian Wen,Liaobin Chen

International journal of molecular sciences 22: PubMed34203369

2021

Electrophysiological and Structural Remodeling of the Atria in a Mouse Model of Troponin-I Mutation Linked Hypertrophic Cardiomyopathy: Implications for Atrial Fibrillation.

Applications

Unspecified application

Species

Unspecified reactive species

Wei-Wen Lim,Melissa Neo,Shivshankar Thanigaimani,Pawel Kuklik,Anand N Ganesan,Dennis H Lau,Tatiana Tsoutsman,Jonathan M Kalman,Christopher Semsarian,David A Saint,Prashanthan Sanders
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com