JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB69036

Anti-TINAGL1 antibody

4

(2 Reviews)

|

(2 Publications)

Mouse Polyclonal TINAGL1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TINAGL1.

View Alternative Names

GIS5, LCN7, OLRG2, TINAGL, PP6614, PSEC0088, UNQ204/PRO230, TINAGL1, Tubulointerstitial nephritis antigen-like, Glucocorticoid-inducible protein 5, Oxidized LDL-responsive gene 2 protein, Tubulointerstitial nephritis antigen-related protein, OLRG-2, TIN Ag-related protein, TIN-Ag-RP

1 Images
Western blot - Anti-TINAGL1 antibody (AB69036)
  • WB

Unknown

Western blot - Anti-TINAGL1 antibody (AB69036)

All lanes:

Western blot - Anti-TINAGL1 antibody (ab69036) at 1/500 dilution

Lane 1:

TINAGL1 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 52 kDa

Observed band size: 53 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TINAGL1.

Q9GZM7

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TINAGL1 also known as Tubulointerstitial Nephritis Antigen Like 1 is an extracellular matrix protein with an approximate mass of 52 kDa. The protein also referred to as TIN-ag localizes primarily in kidney tissues but presents in other tissues like the lung and heart. It associates in the basement membranes of these tissues playing a significant mechanical role in structural integrity and cellular frameworks.
Biological function summary

TINAGL1 facilitates protein interactions that modulate cellular adhesion and migration. It does not belong to any known larger protein complexes but still plays an essential role in maintaining cellular structures. Furthermore TINAGL1 contributes to processes such as angiogenesis and tumor suppression through its interaction with matrix proteins and signaling receptors.

Pathways

TINAGL1 engages in important signaling cascades including the integrin-mediated pathway and the PI3K/Akt pathway. Within these pathways TINAGL1's function closely ties to integrins a group of proteins pivotal for cell adhesion and signal transduction. The protein works alongside fibronectin and collagen establishing pivotal communication for cellular responses to environmental cues.

TINAGL1 involvement extends to certain renal conditions and cancer types. Specifically in kidney diseases like glomerulonephritis TINAGL1 interaction with nephronectin may influence disease progression. In cancer it associates with various oncogenes offering potential as a tumor suppressor in breast cancer where it interacts with proteins like laminin. Such relationships highlight TINAGL1's potential as a target for developing novel therapeutic strategies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).
See full target information TINAGL1
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of the American Society of Nephrology : JA 25:953-66 PubMed24436469

2014

Glomerular cell cross-talk influences composition and assembly of extracellular matrix.

Applications

Unspecified application

Species

Unspecified reactive species

Adam Byron,Michael J Randles,Jonathan D Humphries,Aleksandr Mironov,Hellyeh Hamidi,Shelley Harris,Peter W Mathieson,Moin A Saleem,Simon C Satchell,Roy Zent,Martin J Humphries,Rachel Lennon

Journal of the American Society of Nephrology : JA 25:939-51 PubMed24436468

2014

Global analysis reveals the complexity of the human glomerular extracellular matrix.

Applications

Unspecified application

Species

Human

Rachel Lennon,Adam Byron,Jonathan D Humphries,Michael J Randles,Alex Carisey,Stephanie Murphy,David Knight,Paul E Brenchley,Roy Zent,Martin J Humphries
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB68013

Anti-PITPNC1 antibody

Western blot - Anti-PITPNC1 antibody (AB68013)

  • 0
  • 0
Primary Antibodies

AB254938

Anti-VGLL3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-VGLL3 antibody (AB254938)

  • 0
  • 0
Primary Antibodies

AB14602

Anti-PDE1C/PDE1 antibody

Western blot - Anti-PDE1C/PDE1 antibody (AB14602)

  • 0
  • 0
Primary Antibodies

AB224221

Anti-WDHD1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-WDHD1 antibody (AB224221)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com