Rabbit Polyclonal TIPE2 antibody. Suitable for WB and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human TNFAIP8L2.
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- Allergologia et immunopathologia 51:36-442023Long noncoding RNA ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKun Gao,Aiai Lv,Qiang Zhang,Yanzhong Li,Zhiyong Yue,Shuai XuPubMed 36916086
- The Tohoku journal of experimental medicine 257:181-1912022The Importance of Tumor Necrosis Factor-α-Induced Protein-8 Like-2 in the Pathogenesis of Cervical Cancer and Preeclampsia via Regulation of Cell Invasion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHong Zhang,Wen-Jun Han,Zhi-Lei ZhangPubMed 35418534
- Journal of bioenergetics and biomembranes 52:279-2892020TIPE2 suppresses progression and tumorigenesis of the oral tongue squamous cell carcinoma by regulating FoxP3 regulatory T cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi-Li ZhaoPubMed 32594290
- Human reproduction (Oxford, England) 35:1377-13902020TIPE2 inhibits the migration and invasion of endometrial cells by targeting β-catenin to reverse epithelial-mesenchymal transition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuqiu Liu,Xiaoyan Wang,Lu Wan,Xihong Liu,Huayun Yu,Derui Zhang,Yingshuo Sun,Yongyu Shi,Lining Zhang,Huaiyu Zhou,Jianing Wang,Zengtao WeiPubMed 32469403
- FEBS open bio 10:761-7662020Down-regulation of anti-inflammatory TIPE2 may aggravate adenoidal hypertrophy in children.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKun Gao et. al.PubMed 32100476
- Open life sciences 14:528-5362019Immune Negative Regulator TIPE2 Inhibits Cervical Squamous Cancer Progression Through Erk1/2 Signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi-Qiong Huang,Bo Zheng,Yi HePubMed 33817189
- Biomolecules 9:2019TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDevivasha Bordoloi,Kishore Banik,Ganesan Padmavathi,Rajesh Vikkurthi,Choudhary Harsha,Nand Kishor Roy,Anuj Kumar Singh,Javadi Monisha,Hong Wang,Alan Prem Kumar,Ajaikumar B KunnumakkaraPubMed 31817720
- The Journal of infectious diseases 220:1008-10182019TIPE2 Suppresses Pseudomonas aeruginosa Keratitis by Inhibiting NF-κB Signaling and the Infiltration of Inflammatory Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQun Wang,Li Ma,Ting Liu,Cheng Ge,Qingjun Zhou,Chao Wei,Weiyun ShiPubMed 31067300
- Journal of translational medicine 16:72018TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/β-catenin pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLinan Zhu et. al.PubMed 29343267
- Molecular medicine reports 17:952-9602017TIPE2 governs macrophage polarization via negative regulation of mTORC1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuan Jiang,Qiang Li,Yuanyuan Zhang,Yuzhi Gao,Libing Jiang,Zhimin ChenPubMed 29115630
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TNFAIP8L2. The exact immunogen used to generate this antibody is proprietary information. Database link Q6P589
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
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Target data
Function
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis (PubMed:27043859). Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:32188758). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:32460619). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity).
Alternative names
Tumor necrosis factor alpha-induced protein 8-like protein 2, TIPE2, TNF alpha-induced protein 8-like protein 2, TNFAIP8-like protein 2, Inflammation factor protein 20, TNFAIP8L2
Recommended products
Rabbit Polyclonal TIPE2 antibody. Suitable for WB and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human TNFAIP8L2.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TNFAIP8L2. The exact immunogen used to generate this antibody is proprietary information. Database link Q6P589
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TIPE2 also known as TNFAIP8L2 is a member of the TNFAIP8 family of proteins with a molecular mass of approximately 23 kDa. Mechanically TIPE2 acts as a regulator of cell death and survival processes playing a role in modulating immune responses. It is expressed in a variety of tissues but particularly abundant in immune-related cells such as macrophages and lymphocytes. The protein influences signaling pathways by interacting with other molecules in the cell affecting downstream responses.
- Biological function summary
TIPE2 functions as a negative regulator of immune signaling pathways providing a check against excessive immune activation. It is a cytosolic protein that does not form part of a larger protein complex but can interact with membrane-associated signaling proteins. TIPE2 inhibits both NF-kB and MAPK signaling pathways which are important in mediating immune responses and inflammation. This regulatory function is essential for maintaining immune homeostasis and preventing inflammatory disorders.
- Pathways
Research has highlighted that TIPE2 is integrated within immune signaling cascades particularly impacting the NF-kB and MAPK pathways. These pathways play pivotal roles in inflammation and immune system activation. TIPE2 acts to inhibit the activation of proteins like IKK and JNK which are key mediators within these pathways. By suppressing these pathways TIPE2 helps to balance immune responses and prevent overactivation that can lead to disease states.
- Associated diseases and disorders
TIPE2 has been associated with autoimmune diseases and cancer. Insufficient TIPE2 expression or function can lead to autoimmune disorders like rheumatoid arthritis where unchecked immune signaling causes tissue damage. Conversely overexpression might contribute to cancer progression by dampening anti-tumor immune responses. TIPE2’s interaction with TNFAIP8 family proteins has shown implications in tumor progression highlighting its dual role in modulating immune responses and potential for therapeutic targeting.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-TIPE2 antibody (ab110389)
All lanes: Western blot - Anti-TIPE2 antibody (ab110389) at 1/500 dilution
Lane 1: Extracts from HuvEc cells at 30 µg
Lane 2: Extracts from HuvEc cells at 30 µg with blocking peptide
Predicted band size: 21 kDa
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