AB110389

Anti-TIPE2 antibody

Name: Anti-TIPE2 antibody (ab110389) | Abcam
Brand: Abcam Limited
SKU: AB110389
Price: 535 USD
Availability: InStock

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(15 Publications)

Rabbit Polyclonal TIPE2 antibody. Suitable for WB and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human TNFAIP8L2.

View Alternative Names

Tumor necrosis factor alpha-induced protein 8-like protein 2, TIPE2, TNF alpha-induced protein 8-like protein 2, TNFAIP8-like protein 2, Inflammation factor protein 20, TNFAIP8L2

1 Images

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Western blot - Anti-TIPE2 antibody (AB110389)

All lanes:

Western blot - Anti-TIPE2 antibody (ab110389) at 1/500 dilution

Lane 1:

Extracts from HuvEc cells at 30 µg

Lane 2:

Extracts from HuvEc cells at 30 µg with blocking peptide

Predicted band size: 21 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human TNFAIP8L2. The exact immunogen used to generate this antibody is proprietary information.

Q6P589

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TIPE2 also known as TNFAIP8L2 is a member of the TNFAIP8 family of proteins with a molecular mass of approximately 23 kDa. Mechanically TIPE2 acts as a regulator of cell death and survival processes playing a role in modulating immune responses. It is expressed in a variety of tissues but particularly abundant in immune-related cells such as macrophages and lymphocytes. The protein influences signaling pathways by interacting with other molecules in the cell affecting downstream responses.

Biological function summary

TIPE2 functions as a negative regulator of immune signaling pathways providing a check against excessive immune activation. It is a cytosolic protein that does not form part of a larger protein complex but can interact with membrane-associated signaling proteins. TIPE2 inhibits both NF-kB and MAPK signaling pathways which are important in mediating immune responses and inflammation. This regulatory function is essential for maintaining immune homeostasis and preventing inflammatory disorders.

Pathways

Research has highlighted that TIPE2 is integrated within immune signaling cascades particularly impacting the NF-kB and MAPK pathways. These pathways play pivotal roles in inflammation and immune system activation. TIPE2 acts to inhibit the activation of proteins like IKK and JNK which are key mediators within these pathways. By suppressing these pathways TIPE2 helps to balance immune responses and prevent overactivation that can lead to disease states.

TIPE2 has been associated with autoimmune diseases and cancer. Insufficient TIPE2 expression or function can lead to autoimmune disorders like rheumatoid arthritis where unchecked immune signaling causes tissue damage. Conversely overexpression might contribute to cancer progression by dampening anti-tumor immune responses. TIPE2’s interaction with TNFAIP8 family proteins has shown implications in tumor progression highlighting its dual role in modulating immune responses and potential for therapeutic targeting.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis (PubMed : 27043859). Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed : 32188758). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed : 32460619). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity).

See full target information TNFAIP8L2

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Publications (15)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:27954 PubMed40745253

2025

TIPE2 combined with immune cell infiltration predicts prognosis in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hengbo Xia,Qingqing Pang,Aman Xu,Jie Hu

Allergologia et immunopathologia 51:36-44 PubMed36916086

2023

Long noncoding RNA ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating axis.

Applications

Unspecified application

Species

Unspecified reactive species

Kun Gao,Aiai Lv,Qiang Zhang,Yanzhong Li,Zhiyong Yue,Shuai Xu

Experimental and therapeutic medicine 24:613 PubMed36160908

2022

TIPE2 protects cardiomyocytes from ischemia-reperfusion-induced apoptosis by decreasing cell autophagy via the mTORC1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Gong Cheng,Xiaoyan Huang,Penghua You,Panpan Feng,Shuo Jia,Ji Zhang,Hongjun You,Fengjun Chang

The Tohoku journal of experimental medicine 257:181-191 PubMed35418534

2022

The Importance of Tumor Necrosis Factor-α-Induced Protein-8 Like-2 in the Pathogenesis of Cervical Cancer and Preeclampsia via Regulation of Cell Invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Zhang,Wen-Jun Han,Zhi-Lei Zhang

Journal of bioenergetics and biomembranes 52:279-289 PubMed32594290

2020

TIPE2 suppresses progression and tumorigenesis of the oral tongue squamous cell carcinoma by regulating FoxP3 regulatory T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Li Zhao

Human reproduction (Oxford, England) 35:1377-1390 PubMed32469403

2020

TIPE2 inhibits the migration and invasion of endometrial cells by targeting β-catenin to reverse epithelial-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Yuqiu Liu,Xiaoyan Wang,Lu Wan,Xihong Liu,Huayun Yu,Derui Zhang,Yingshuo Sun,Yongyu Shi,Lining Zhang,Huaiyu Zhou,Jianing Wang,Zengtao Wei

Cell biology international 44:1691-1700 PubMed32298032

2020

Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yanyan Xu,Jing Wang,Hong Ding

FEBS open bio 10:761-766 PubMed32100476

2020

Down-regulation of anti-inflammatory TIPE2 may aggravate adenoidal hypertrophy in children.

Applications

Unspecified application

Species

Unspecified reactive species

Kun Gao,Yanzhong Li,Zhiyong Yue,Jie Han,Xuanchen Zhou,Xiaoting Wang

Open life sciences 14:528-536 PubMed33817189

2019

Immune Negative Regulator TIPE2 Inhibits Cervical Squamous Cancer Progression Through Erk1/2 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Qiong Huang,Bo Zheng,Yi He

Biomolecules 9: PubMed31817720

2019

TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade.

Applications

Unspecified application

Species

Unspecified reactive species

Devivasha Bordoloi,Kishore Banik,Ganesan Padmavathi,Rajesh Vikkurthi,Choudhary Harsha,Nand Kishor Roy,Anuj Kumar Singh,Javadi Monisha,Hong Wang,Alan Prem Kumar,Ajaikumar B Kunnumakkara

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-TIPE2 antibody

Western blot - Anti-TIPE2 antibody (AB110389)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (15)

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