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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Recombinant Monoclonal TKTL2 antibody. Suitable for IHC-P, WB and reacts with Human samples.
IgG
Rabbit
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
Liquid
Monoclonal
IHC-P | IP | Flow Cyt | WB | |
---|---|---|---|---|
Human | Tested | Not recommended | Not recommended | Tested |
Mouse | Predicted | Not recommended | Not recommended | Predicted |
Rat | Predicted | Not recommended | Not recommended | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100 - 1/250 | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human, Mouse, Rat | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human, Mouse, Rat | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/1000 - 1/10000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.
Transketolase-like protein 2, TKTL2
Rabbit Recombinant Monoclonal TKTL2 antibody. Suitable for IHC-P, WB and reacts with Human samples.
Transketolase-like protein 2, TKTL2
IgG
Rabbit
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
Liquid
Monoclonal
EPR8592
Affinity purification Protein A
2.29 x 10-11 M
Blue Ice
-20°C
Stable for 12 months at -20°C
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
TKTL2 contributes to cellular processes related to energy metabolism and biosynthesis. It forms a functional relationship with other proteins in metabolic pathways participating in the regulation of cellular redox balance and nucleotide biosynthesis. This enzyme supports cellular functions by contributing to the generation of ribose-5-phosphate a precursor for nucleotide synthesis and NADPH essential for anabolic reactions and antioxidative defenses.
Transketolase-like 2 (TKTL2) also known as TKL2 is an enzyme involved in carbohydrate metabolism. Its molecular weight is approximately 70 kDa. TKTL2 expression occurs broadly in human tissues with reported high expression levels in the heart brain and liver. The enzyme plays an important role in the non-oxidative part of the pentose phosphate pathway where it influences the interconversion of sugar phosphates.
TKTL2 significantly participates in the pentose phosphate pathway and is implicated in glycolysis connecting to numerous other enzymes like glucose-6-phosphate dehydrogenase. Its activity affects the levels of critical metabolites within these pathways thereby influencing cell survival and proliferation. The interaction of TKTL2 with these pathways highlights its role in regulating cellular metabolic flux impacting processes such as ribonucleotide synthesis and redox homeostasis.
TKTL2 has been associated with cancer particularly in tumor progression and metastasis. Aberrant expression of TKTL2 correlates with altered metabolic states within cancer cells linking it to enhanced tumor growth. It is also suggested that TKTL2 might relate to neurodegenerative conditions where its expression aligns with neuronal metabolic demands and oxidative stress resistance. Research also connects TKTL2 with proteins like lactate dehydrogenase in the context of cancer metabolism illustrating the enzyme's relevance in disease states.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
All lanes: Western blot - Anti-TKTL2 antibody [EPR8592] (AB131331) at 1/1000 dilution
Lane 1: Jurkat cell lysate at 10 µg
Lane 2: HepG2 cell lysate at 10 µg
Lane 3: BxPC-3 cell lysate at 10 µg
Lane 4: MCF7 cell lysate at 10 µg
All lanes: Goat anti-rabbit HRP at 1/2000 dilution
Predicted band size: 68 kDa
Immunohistochemical analysis of paraffin-embedded Human hepatocellular carcinoma tissue labelling TKTL2 with ab131331 at 1/100 dilution.
Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody.
Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com