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AB206147

Anti-TLE2 antibody

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(1 Publication)

Rabbit Polyclonal TLE2 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transducin-like enhancer protein 2 aa 400-650.

View Alternative Names

Transducin-like enhancer protein 2, Enhancer of split groucho-like protein 2, ESG2, TLE2

1 Images
Western blot - Anti-TLE2 antibody (AB206147)
  • WB

Supplier Data

Western blot - Anti-TLE2 antibody (AB206147)

All lanes:

Western blot - Anti-TLE2 antibody (ab206147) at 1/500 dilution

All lanes:

Rat lung lysate

Predicted band size: 80 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human Transducin-like enhancer protein 2 aa 400-650. The exact immunogen used to generate this antibody is proprietary information.

Q04725

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 98% PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TLE2 also known as Transducin-Like Enhancer of Split 2 is a member of the Groucho/TLE family of co-repressors. It has a molecular mass of approximately 82 kDa. TLE2 is expressed in various tissues including brain and muscle. As a protein it interacts with transcription factors repressing transcription by binding to DNA-binding proteins which ultimately influences gene expression and cellular differentiation.
Biological function summary

TLE2 serves as a general transcriptional co-repressor. It forms complexes with other transcriptional regulators to modulate gene expression participating in the repression of transcriptional activity. TLE2 shows a significant role in embryonic development and neuronal differentiation working alongside other Groucho family members to guide cell fate decisions during development.

Pathways

TLE2 interacts with a range of signaling mechanisms involved in development and differentiation. It is notably involved in the Notch signaling pathway which regulates cell differentiation and proliferation. Additionally TLE2 associates with Wnt signaling interacting with other proteins like LEF1 and TCF to suppress Wnt target genes. These interactions contribute to maintaining a balance between cell proliferation and differentiation.

TLE2 has connections to several neurological conditions. Altered expression or function of TLE2 is linked to neurodevelopmental disorders including autism spectrum disorder. Furthermore disruptions in its interaction with other proteins like LEF1 influence pathological processes associated with cancer particularly in brain tumors. Understanding TLE2's role in these conditions helps in unraveling the molecular mechanisms underlying disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
See full target information Transducin-like enhancer protein 2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Annals of translational medicine 8:1017 PubMed32953817

2020

TLE2 is associated with favorable prognosis and regulates cell growth and gemcitabine sensitivity in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Shixiong Hu,Zhengbo Chen,Jinling Gu,Liyang Tan,Meifeng Zhang,Weidong Lin
View all publications
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