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AB233827

Anti-TLL1 antibody [4H8C1]

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(1 Publication)

Mouse Monoclonal TLL1 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TLL1 aa 850 to C-terminus.

View Alternative Names

TLL, TLL1, Tolloid-like protein 1

3 Images
Flow Cytometry - Anti-TLL1 antibody [4H8C1] (AB233827)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-TLL1 antibody [4H8C1] (AB233827)

Flow cytometric analysis of HeLa (human epithelial cell line from cervix adenocarcinoma) cell line labeling TLL1 with ab233827 at 1/200 dilution (green) compared with a negative control (red).

Western blot - Anti-TLL1 antibody [4H8C1] (AB233827)
  • WB

Supplier Data

Western blot - Anti-TLL1 antibody [4H8C1] (AB233827)

Expected MW is 42.2

All lanes:

Western blot - Anti-TLL1 antibody [4H8C1] (ab233827) at 1/500 dilution

All lanes:

Recombinant human TLL1 (AA: 870-1013)

Predicted band size: 115 kDa

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Western blot - Anti-TLL1 antibody [4H8C1] (AB233827)
  • WB

Supplier Data

Western blot - Anti-TLL1 antibody [4H8C1] (AB233827)

Lanes 1 - 2:

Western blot - Anti-MGLUR8 antibody [4C1C1] (<a href='/en-us/products/primary-antibodies/mglur8-antibody-4c1c1-ab233791'>ab233791</a>) at 1/500 dilution

Lanes 1 - 2:

Western blot - Anti-TLL1 antibody [4H8C1] (ab233827)

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) whole cell lysate

Lane 2:

TLL1 (AA: 870-1013)-hIgGFc transfected HEK-293 whole cell lysate

Predicted band size: 102 kDa,115 kDa

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Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

4H8C1

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, WB

applications

Immunogen

Recombinant Fragment Protein within Human TLL1 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43897

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TLL1 also known as tolloid-like protein 1 is a metalloprotease with an approximate mass of 105 kDa. TLL1 belongs to the astacin family of zinc-dependent metalloproteinases. It cleaves specific protein substrates playing a critical role in tissue remodeling and development. This protein is mainly expressed in the heart lungs and skeletal tissue indicating its importance in these organs.
Biological function summary

The functions of tolloid-like protein 1 are essential for embryonic development particularly in heart morphogenesis. TLL1 forms part of a protein complex that regulates the activation of latent growth factors. It facilitates the maturation of certain extracellular matrix components by cleaving procollagen C-propeptides. Such activity is central to ensuring proper extracellular matrix organization and subsequent tissue integrity.

Pathways

The enzymatic actions of TLL1 integrate into critical signaling pathways such as the Transforming Growth Factor-beta (TGF-β) and Bone Morphogenetic Protein (BMP) signaling pathways. TLL1 modulates these pathways by processing various latent growth factors. It shares functional similarities with related proteins like BMP1 another known metalloprotease by orchestrating cellular communication and tissue formation processes which are vital for proper cellular events.

Tolloid-like protein 1 has been associated with congenital heart defects due to its indispensable role in heart development. Mutations or malfunctions in TLL1 can lead to maladaptive morphogenesis of cardiac tissues. Moreover research indicates a link between TLL1 and fibrotic conditions. Alterations in its activity can disrupt normal tissue fibrosis processes and involve proteins like TGF-β leading to pathological fibrosis in tissues such as the heart and lungs.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
See full target information TLL1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Archives of medical science : AMS 20:1631-1654 PubMed39649262

2023

Oxymatrine inhibits the development of radioresistance in NSCLC cells by reversing EMT through the DcR3/AKT/GSK-3β pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jianming Tang,Yu Cao,Hong Zhang,Rui Wang
View all publications
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