AB113446

Anti-TLR10 antibody [3C10C5]

Name: Anti-TLR10 antibody [3C10C5] (ab113446) | Abcam
Brand: Abcam Limited
SKU: AB113446

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(3 Publications)

Mouse Monoclonal TLR10 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TLR10 aa 1-500.

View Alternative Names

CD290, UNQ315/PRO358, TLR10, Toll-like receptor 10

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

3C10C5

Isotype

IgG1

Light chain type

kappa

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human TLR10 aa 1-500. The exact immunogen used to generate this antibody is proprietary information.

Q9BXR5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TLR10 also known as Toll-like receptor 10 is part of the Toll-like receptor family and its molecular weight is approximately 90 kDa. TLR10 is expressed in various tissues more particularly in immune cells such as B cells monocytes and dendritic cells. It plays a mechanical role in recognizing pathogen-associated molecular patterns which is important for the activation of innate immune responses.

Biological function summary

TLR10 is involved in mediating immune system responses against pathogens. While it has shown similarities with other toll-like receptors its exact ligands and signaling pathways are still under investigation. TLR10 may exist as part of a receptor complex which helps in transmitting signals from pathogens to activate appropriate immune responses. This receptor's involvement suggests it has an important role in innate immunity and inflammation regulation.

Pathways

Several scientific studies have indicated that TLR10 participates in the innate immune signaling pathways. It potentially interacts with components of the TLR signaling pathway similar to other members of the TLR family like TLR2 and TLR4. Through the MyD88-dependent signaling pathway TLR10 may activate transcription factors such as NF-kB which leads to the production of pro-inflammatory cytokines. These interactions suggest TLR10 is important for modulating immune responses.

Researchers have linked TLR10 to inflammatory conditions and immune system disorders. Current research shows that altered expression or function of TLR10 could relate to autoimmune diseases like rheumatoid arthritis through its influence on immune cell activation. Additionally TLR10 has connections to certain cancers as inflammation pathways can also contribute to cancer development. TLR10 in conjunction with other Toll-like receptors may influence disease progression and offers potential as a therapeutic target.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

See full target information TLR10

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of innate immunity 16:96-104 PubMed38246135

2024

TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions.

Applications

Unspecified application

Species

Unspecified reactive species

Carolina Rego Rodrigues,Yadu Balachandran,Gurpreet Kaur Aulakh,Baljit Singh

Journal of innate immunity 14:629-642 PubMed35613551

2022

Regulation of TLR10 Expression and Its Role in Chemotaxis of Human Neutrophils.

Applications

Unspecified application

Species

Unspecified reactive species

Yadu Balachandran,Sarah Caldwell,Gurpreet Kaur Aulakh,Baljit Singh

Frontiers in molecular neuroscience 14:688050 PubMed34630032

2021

Tandem Mass Tag-Based Quantitative Proteomic Analysis Reveals Pathways Involved in Brain Injury Induced by Chest Exposure to Shock Waves.

Applications

Unspecified application

Species

Unspecified reactive species

Changci Tong,Peifang Cong,Ying Liu,Xiuyun Shi,Lin Shi,Shun Mao,Yan Zhao,Mingxiao Hou,Yunen Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TLR10 antibody [3C10C5]

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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