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AB21273

Anti-TLR10 antibody

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(1 Publication)

Rabbit Polyclonal TLR10 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TLR10.

View Alternative Names

CD290, UNQ315/PRO358, TLR10, Toll-like receptor 10

1 Images
Western blot - Anti-TLR10 antibody (AB21273)
  • WB

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Western blot - Anti-TLR10 antibody (AB21273)

Lane 1:

Western blot - Anti-TLR10 antibody (ab21273) at 0.5 µg/mL

Lane 2:

Western blot - Anti-TLR10 antibody (ab21273) at 1 µg/mL

All lanes:

Human lymph node cell lysates

Predicted band size: 95 kDa

Observed band size: 75 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TLR10. The exact immunogen used to generate this antibody is proprietary information.

Q9BXR5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Ion exchange chromatography.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TLR10 also known as Toll-like receptor 10 is part of the Toll-like receptor family and its molecular weight is approximately 90 kDa. TLR10 is expressed in various tissues more particularly in immune cells such as B cells monocytes and dendritic cells. It plays a mechanical role in recognizing pathogen-associated molecular patterns which is important for the activation of innate immune responses.
Biological function summary

TLR10 is involved in mediating immune system responses against pathogens. While it has shown similarities with other toll-like receptors its exact ligands and signaling pathways are still under investigation. TLR10 may exist as part of a receptor complex which helps in transmitting signals from pathogens to activate appropriate immune responses. This receptor's involvement suggests it has an important role in innate immunity and inflammation regulation.

Pathways

Several scientific studies have indicated that TLR10 participates in the innate immune signaling pathways. It potentially interacts with components of the TLR signaling pathway similar to other members of the TLR family like TLR2 and TLR4. Through the MyD88-dependent signaling pathway TLR10 may activate transcription factors such as NF-kB which leads to the production of pro-inflammatory cytokines. These interactions suggest TLR10 is important for modulating immune responses.

Researchers have linked TLR10 to inflammatory conditions and immune system disorders. Current research shows that altered expression or function of TLR10 could relate to autoimmune diseases like rheumatoid arthritis through its influence on immune cell activation. Additionally TLR10 has connections to certain cancers as inflammation pathways can also contribute to cancer development. TLR10 in conjunction with other Toll-like receptors may influence disease progression and offers potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
See full target information TLR10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 13:3265-72 PubMed26936681

2016

Downregulation of VEGF and upregulation of TL1A expression induce HUVEC apoptosis in response to high glucose stimuli.

Applications

Unspecified application

Species

Unspecified reactive species

Miao Yu,Guihua Lu,Xun Zhu,Zhibin Huang,Chong Feng,Rong Fang,Yesong Wang,Xiuren Gao
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Product promise

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