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AB113524

Anti-TLR7 antibody

1

(1 Review)

|

(7 Publications)

Rabbit Polyclonal TLR7 antibody. Suitable for WB, IHC-P and reacts with Human, Chimpanzee, Monkey samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human TLR7 aa 900-950 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

UNQ248/PRO285, TLR7, Toll-like receptor 7

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR7 antibody (AB113524)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR7 antibody (AB113524)

ab113524, at 10 μg/ml, staining TLR7 in formalin fixed, paraffin embedded Human placenta tissue by immunohistochemistry.

Western blot - Anti-TLR7 antibody (AB113524)
  • WB

Unknown

Western blot - Anti-TLR7 antibody (AB113524)

All lanes:

Western blot - Anti-TLR7 antibody (ab113524) at 1 µg/mL

Lane 1:

Ramos cell lysate

Lane 2:

Ramos cell lysate with immunizing peptide

Predicted band size: 121 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR7 antibody (AB113524)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR7 antibody (AB113524)

ab113524, at 10 μg/ml, staining TLR7 in formalin fixed, paraffin embedded Human lung tissue by immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Chimpanzee, Monkey

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human TLR7 aa 900-950 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9NYK1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TLR7 also known as Toll-like receptor 7 plays a mechanical role in the immune system by recognizing single-stranded RNA molecules. This receptor with a mass of approximately 120 kDa is a member of the Toll-like receptor family. TLR7 mainly expresses in immune cells like plasmacytoid dendritic cells and B cells. Its location on the endosomal surface allows it to detect viral RNA and trigger downstream signaling cascades.
Biological function summary

TLR7 induces an immune response by activating pathways that lead to the production of cytokines and type I interferons. It does not function alone but interacts within a complex involving other adaptors such as MyD88. This interaction initiates a signaling cascade that is essential for mounting an acute response to viral infections and boosting adaptive immunity.

Pathways

Single-stranded RNA detection through TLR7 activates the MyD88-dependent pathway which is important for innate immune responses. This pathway includes key components such as NF-κB and IRF7 leading to inflammatory cytokine production. TLR7 links with these proteins working together to activate the host defense mechanism against viral infections.

TLR7 plays a significant role in autoimmunity and viral infections. Aberrant activation of TLR7 has connections with systemic lupus erythematosus (SLE) where it may contribute to pathogenesis by promoting autoantibody production. Additionally TLR7 influences the immune response in chronic infections like hepatitis C where it operates with proteins like MyD88 and contributes to disease progression and severity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed : 14976261, PubMed : 32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed : 12738885, PubMed : 27742543, PubMed : 31608988, PubMed : 32706371, PubMed : 35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed : 27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed : 27742543, PubMed : 32706371).
See full target information TLR7
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Journal of hypertension 43:1675-1685 PubMed40704393

2025

Overexpression of TLR7 contributes to the development of preeclampsia through suppression of the PI3K-Akt signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowei Zhang,Shilin Zhong,Ping Yang,Xinyang Liu,Jinli Lyu,Yuzhen Ding,Qiaoli Feng,Yiheng Liang,Ping Liu,Chunfeng Liu,Yanlan Wang,Yuxia Zhu,Liting Huang,Zhansong Xiao,Pingyue Zhao,Qing Li,Kaidong Ma,Shangrong Fan

Journal of gastroenterology and hepatology 39:2892-2902 PubMed39343436

2024

RNA-binding protein Trx regulates alternative splicing and promotes metastasis of HCC via interacting with LINC00152.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangnan Teng,Jin Shang,Lingyao Du,Wei Huang,Yonghong Wang,Miao Liu,Yuanji Ma,Ming Wang,Hong Tang,Lang Bai

Molecular neurobiology 59:2629-2641 PubMed35141864

2022

C/EBPβ Participates in Nerve Trauma-Induced TLR7 Upregulation in Primary Sensory Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Long He,Jing Cao,Bao-Chun Jiang,Jian-Jun Yang,Yuan-Xiang Tao,Yanqiu Ai

International journal of pharmaceutics 616:121466 PubMed35065205

2022

Evaluation of immune-modulating drugs for use in drug-eluting microsphere transarterial embolization.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew S Mikhail,Michal Mauda-Havakuk,Ayele H Negussie,Natalie Hong,Natalie M Hawken,Camella J Carlson,Joshua W Owen,Olga Franco-Mahecha,Paul G Wakim,Andrew L Lewis,William F Pritchard,John W Karanian,Bradford J Wood

EMBO molecular medicine 14:e14455 PubMed34936223

2021

Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuyu Zhu,Zhigui Wu,Wei Yan,Fenli Shao,Bowen Ke,Xian Jiang,Jian Gao,Wenjie Guo,Yuping Lai,Hongyue Ma,Dijun Chen,Qiang Xu,Yang Sun

Animal reproduction 18:e20210009 PubMed34394755

2021

Early pregnancy affects expression of Toll-like receptor signaling members in ovine spleen.

Applications

Unspecified application

Species

Unspecified reactive species

Leying Zhang,Gengxin Yang,Qiongao Zhang,Pengfei Feng,Meihong Gao,Ling Yang

Science advances 1:e1400183 PubMed26601192

2015

Role of Toll-like receptors in diabetic renal lesions in a miniature pig model.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Feng,Shulin Yang,Yuxiang Ma,Xue-Yuan Bai,Xiangmei Chen
View all publications
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