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AB192619

Anti-TLT-1 antibody [EP15294]

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(1 Publication)

Rabbit Monoclonal TLT-1 antibody. Suitable for ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication.

View Alternative Names

TLT1, UNQ1825/PRO3438, TREML1, Trem-like transcript 1 protein, TLT-1, Triggering receptor expressed on myeloid cells-like protein 1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-TLT-1 antibody [EP15294] (AB192619)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TLT-1 antibody [EP15294] (AB192619)

Immunofluorescent analysis of Jurkat cells (4% Paraformaldehyde-fixed, 0.1% tritonX-100 permeabilized) labeling TLT-1 with ab192619 at 1/50 dilution (1.6 μg/ml). A Goat anti rabbit IgG (Alexa Fluor488) at 1/400 dilution (ab150077) was used as secondary antibody. Counterstain : DAPI.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLT-1 antibody [EP15294] (AB192619)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLT-1 antibody [EP15294] (AB192619)

Immunohistochemical analysis of paraffin-embedded Human spleen tissue labeling TLT-1 with ab192619 at 1/1000 dilution (0.08μg/ml). A Ready to use HRP Polymer for Rabbit IgG (prediluted) was used as secondary. Counterstain : Hematoxylin.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EP15294

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TLT-1 or TREM-like transcript 1 is a receptor expressed on platelets and megakaryocytes. Known for a mass of approximately 27 kDa TLT-1 belongs to the immunoglobulin superfamily. This receptor is a type I transmembrane protein and its expression is found mainly in the alpha-granules of resting platelets. During platelet activation TLT-1 translocates to the cell surface where it can participate in various cellular interactions.
Biological function summary

TLT-1 plays a significant role in hemostasis and inflammation. When considering its biological activity TLT-1 is not part of a larger protein complex but it can bind fibrinogen which facilitates clot formation and stability. This binding assists in the regulation of platelet aggregation and assists modulating the inflammatory response during vascular injury. Through its interactions at the molecular level TLT-1 enhances the overall efficiency of the clotting process.

Pathways

TLT-1 contributes to the hemostatic and pro-inflammatory pathways. It plays a part in the regulation of clot formation by interacting with other platelet surface proteins and fibrinogen. TLT-1 is associated with pathways such as the platelet activation pathway where it cooperates with proteins like P-selectin to modulate responses to vascular injury. Such interactions ensure that TLT-1 functions as an important component in maintaining circulatory system integrity.

TLT-1 connects to conditions such as thrombosis and sepsis. These disorders involve the dysfunction of the hemostatic and immune systems respectively. In thrombosis TLT-1 may contribute to excessive clot formation often interacting with proteins like fibrinogen in the process. During sepsis TLT-1 takes part in the inflammatory response which can exacerbate the clinical symptoms of the condition. Understanding the role of TLT-1 could aid in developing therapeutic targets aimed at modulating both coagulation and inflammation processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell surface receptor that may play a role in the innate and adaptive immune response.
See full target information TREML1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic surgery and research 20:539 PubMed40442730

2025

Insights into the potential role of BMSCs-exo delivered USP14 on SIRT1 deubiquitination in Staphylococcus aureus-induced model of osteomyelitis.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Yu,Ming Yang,Yun Jin,Kaijie Yang,Haibo Yang
View all publications
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Product promise

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