JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB78498

Anti-TLX1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal TLX1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TLX1 aa 300 to C-terminus.

View Alternative Names

HOX11, TCL3, TLX1, T-cell leukemia homeobox protein 1, Homeobox protein Hox-11, Proto-oncogene TCL-3, T-cell leukemia/lymphoma protein 3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX1 antibody (AB78498)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX1 antibody (AB78498)

ab78498, at 5μg/ml, staining TLX1 in human thymus tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TLX1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P31314

style
left-column

Alternative Products

Primary Antibodies

AB191270

Anti-TLX1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX1 antibody (AB191270)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB79389

Anti-Pax2 antibody [EP3251]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pax2 antibody [EP3251] (AB79389)

  • 4
  • 11
Primary Antibodies

AB88862

Anti-ZNF468 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF468 antibody (AB88862)

  • 0
  • 0
Primary Antibodies

AB154864

Anti-UGT2B15 antibody [EPR10615(B)]

RabMAb|Recombinant

Western blot - Anti-UGT2B15 antibody [EPR10615(B)] (AB154864)

  • 0
  • 0
Primary Antibodies

AB247736

Anti-TRAF4 antibody [EPR1729] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-TRAF4 antibody [EPR1729] - BSA and Azide free (AB247736)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.2% Gelatin
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TLX1 also known as T-cell leukemia homeobox protein 1 or HOX11 serves as a transcription factor involved in the regulation of various developmental processes. It has an approximate molecular weight of 33 kDa and is primarily expressed in the developing nervous system and specific hematopoietic cells. TLX1 facilitates the binding to DNA at specific sequences to modulate target gene expression playing an essential role during certain developmental stages.
Biological function summary

The homeobox protein TLX1 contributes to the specification of cell identity and regulation of cell proliferation. It does not belong to a complex structure but functions independently to mediate transcriptional activation or repression. Its activity is essential during the development of the spleen and certain T-cell lineages indicating its relevance in embryogenesis and hematopoiesis.

Pathways

TLX1 plays a significant role in the Notch signaling pathway and the Wnt signaling pathway both of which control aspects of cell fate decisions and differentiation processes. TLX1 interacts with components of these pathways such as members of the Notch receptor family and beta-catenin to execute its function in maintaining cellular homeostasis and promoting lineage-specific differentiation.

TLX1 has known associations with T-cell acute lymphoblastic leukemia (T-ALL) and spleen developmental defects. Its aberrant expression interacts with other proteins like TAL1 and LMO1 contributing to leukemic transformation in T-ALL. The presence of TLX1 in these pathological conditions highlights its potential as a therapeutic target or biomarker for diagnosing and monitoring disease progression.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
See full target information TLX1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 7:4523 PubMed28674422

2017

Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Boris Novakovic,Thierry Fournier,Lynda K Harris,Joanna James,Claire T Roberts,Hannah E J Yong,Bill Kalionis,Danièle Evain-Brion,Peter R Ebeling,Euan M Wallace,Richard Saffery,Padma Murthi
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com