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Rabbit Polyclonal TLX1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TLX1 aa 300 to C-terminus.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX1 antibody (AB78498), expandable thumbnail

Publications

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

Preservative: 0.05% Sodium azide
Constituents: PBS, 0.2% Gelatin

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Synthetic Peptide within Human TLX1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P31314

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species
Human
Dilution info
5 µg/mL
Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Alternative names

HOX11, TCL3, TLX1, T-cell leukemia homeobox protein 1, Homeobox protein Hox-11, Proto-oncogene TCL-3, T-cell leukemia/lymphoma protein 3

Recommended products

Rabbit Polyclonal TLX1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TLX1 aa 300 to C-terminus.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Synthetic Peptide within Human TLX1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P31314
Purification technique
Affinity purification Protein G
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

TLX1 also known as T-cell leukemia homeobox protein 1 or HOX11 serves as a transcription factor involved in the regulation of various developmental processes. It has an approximate molecular weight of 33 kDa and is primarily expressed in the developing nervous system and specific hematopoietic cells. TLX1 facilitates the binding to DNA at specific sequences to modulate target gene expression playing an essential role during certain developmental stages.

Biological function summary

The homeobox protein TLX1 contributes to the specification of cell identity and regulation of cell proliferation. It does not belong to a complex structure but functions independently to mediate transcriptional activation or repression. Its activity is essential during the development of the spleen and certain T-cell lineages indicating its relevance in embryogenesis and hematopoiesis.

Pathways

TLX1 plays a significant role in the Notch signaling pathway and the Wnt signaling pathway both of which control aspects of cell fate decisions and differentiation processes. TLX1 interacts with components of these pathways such as members of the Notch receptor family and beta-catenin to execute its function in maintaining cellular homeostasis and promoting lineage-specific differentiation.

Associated diseases and disorders

TLX1 has known associations with T-cell acute lymphoblastic leukemia (T-ALL) and spleen developmental defects. Its aberrant expression interacts with other proteins like TAL1 and LMO1 contributing to leukemic transformation in T-ALL. The presence of TLX1 in these pathological conditions highlights its potential as a therapeutic target or biomarker for diagnosing and monitoring disease progression.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX1 antibody (ab78498), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX1 antibody (ab78498)

    ab78498, at 5μg/ml, staining TLX1 in human thymus tissue.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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