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Rabbit Polyclonal TLX3 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human T-cell leukemia homeobox protein 3 aa 100-200.

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Images

Western blot - Anti-TLX3 antibody (AB184011), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX3 antibody (AB184011), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX3 antibody (AB184011), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human T-cell leukemia homeobox protein 3 aa 100-200. The exact immunogen used to generate this antibody is proprietary information. Database link O43711

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Expected
Mouse
Expected
Tested

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Tested
Tested

Species

Mouse

Dilution info

1/100.00000 - 1/1000.00000

Notes

-

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Alternative names

Recommended products

Rabbit Polyclonal TLX3 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human T-cell leukemia homeobox protein 3 aa 100-200.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human T-cell leukemia homeobox protein 3 aa 100-200. The exact immunogen used to generate this antibody is proprietary information. Database link O43711
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TLX3 also known as T-cell leukemia homeobox protein 3 is a transcription factor with a mass of approximately 33 kDa. It belongs to the homeobox gene family and plays a role in regulating gene expression. TLX3 shows expression mostly in the nervous system and immature T-cells particularly during development. The protein acts by binding to specific DNA sequences leading to activation or suppression of target genes essential for the control of developmental processes.

Biological function summary

TLX3 influences the fate of neuronal cell types and is critical in determining neurotransmitter identity. It functions as part of a regulatory complex that guides the differentiation of neurons especially in the dorsal spinal cord. Its activity impacts pathways that promote the production of excitatory glutamatergic neurons over inhibitory GABAergic neurons ensuring proper balance in the central nervous system.

Pathways

TLX3 operates in the gene regulatory networks connected to neuronal differentiation and survival. It interacts importantly with the Notch signaling pathway influencing neurogenesis and cell fate decisions. TLX3 shares regulatory pathways with proteins such as TLX1 and influences the expression of downstream genes that are required for neuronal identity and function. These interactions indicate its role in diverse neuronal processes.

Associated diseases and disorders

TLX3 is linked to T-cell acute lymphoblastic leukemia (T-ALL) and has implications in certain neurodevelopmental disorders. In T-ALL overexpression of TLX3 disrupts normal T-cell development leading to malignancy. It interacts with proteins like TAL1 contributing to leukemogenesis through modulation of gene networks that control cell proliferation and differentiation. Additionally altered TLX3 expression may correlate with developmental issues in neural patterning showing its importance in both cancer and nervous system diseases.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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3 product images

  • Western blot - Anti-TLX3 antibody (ab184011), expandable thumbnail

    Western blot - Anti-TLX3 antibody (ab184011)

    12% SDS PAGE

    All lanes: Western blot - Anti-TLX3 antibody (ab184011) at 1/1000 dilution

    Lane 1: SK-N-SH whole cell lysate at 30 µg

    Lane 2: IMR32 whole cell lysate at 30 µg

    Lane 3: SK-N-AS whole cell lysate at 30 µg

    Predicted band size: 32 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX3 antibody (ab184011), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX3 antibody (ab184011)

    Immunohistochemical analysis of paraffin-embedded mouse muscle labeling TLX3 using ab184011 at 1/500 dilution

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX3 antibody (ab184011), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLX3 antibody (ab184011)

    Immunohostochemical analysis of paraffin-embedded mouse fore brain labeling TLX3 with ab184011 a 1/500

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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