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AB251804

Anti-TLX3 antibody

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(1 Publication)

Rabbit Polyclonal TLX3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TLX3 aa 50-150.

View Alternative Names

HOX11L2, TLX3, T-cell leukemia homeobox protein 3, Homeobox protein Hox-11L2

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TLX3 antibody (AB251804)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TLX3 antibody (AB251804)

PFA-fixed, Triton X-100 permeabilized SH-SY5Y (human neuroblastoma cell line from bone marrow) cells stained for TLX3 (green) using ab251804 at 4 µg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TLX3 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

O43711

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TLX3 also known as T-cell leukemia homeobox protein 3 is a transcription factor with a mass of approximately 33 kDa. It belongs to the homeobox gene family and plays a role in regulating gene expression. TLX3 shows expression mostly in the nervous system and immature T-cells particularly during development. The protein acts by binding to specific DNA sequences leading to activation or suppression of target genes essential for the control of developmental processes.
Biological function summary

TLX3 influences the fate of neuronal cell types and is critical in determining neurotransmitter identity. It functions as part of a regulatory complex that guides the differentiation of neurons especially in the dorsal spinal cord. Its activity impacts pathways that promote the production of excitatory glutamatergic neurons over inhibitory GABAergic neurons ensuring proper balance in the central nervous system.

Pathways

TLX3 operates in the gene regulatory networks connected to neuronal differentiation and survival. It interacts importantly with the Notch signaling pathway influencing neurogenesis and cell fate decisions. TLX3 shares regulatory pathways with proteins such as TLX1 and influences the expression of downstream genes that are required for neuronal identity and function. These interactions indicate its role in diverse neuronal processes.

TLX3 is linked to T-cell acute lymphoblastic leukemia (T-ALL) and has implications in certain neurodevelopmental disorders. In T-ALL overexpression of TLX3 disrupts normal T-cell development leading to malignancy. It interacts with proteins like TAL1 contributing to leukemogenesis through modulation of gene networks that control cell proliferation and differentiation. Additionally altered TLX3 expression may correlate with developmental issues in neural patterning showing its importance in both cancer and nervous system diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TLX3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 20:354 PubMed32760221

2020

Enhanced expression of microtubule-associated protein 7 functioned as a contributor to cervical cancer cell migration and is predictive of adverse prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Tang,Dan Lyu,Jian-Fang Chang,Zhi-Tao Liu,Yan Zhang,Hai-Ping Liu
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