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AB236904

Anti-TM14A antibody

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(2 Publications)

Rabbit Polyclonal TM14A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM14A aa 1 to C-terminus.

View Alternative Names

C6orf73, PTD011, TMEM14A, Transmembrane protein 14A

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TM14A antibody (AB236904)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TM14A antibody (AB236904)

PC-3 (human prostate adenocarcinoma cell line) cells stained for TM14A (green) using ab236904 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TMEM14A aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6G1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TM14A also known as Transmembrane protein 14A is a protein consisting of 221 amino acids and has a mass of approximately 24.5 kDa. It is mainly located in the plasma membrane where it spans multiple times through the membrane structure. Researchers find TM14A to express prominently in epithelial tissues particularly within the gastrointestinal tract and respiratory system. Given its transmembrane nature it likely plays significant roles in cellular transportation and signaling processes.
Biological function summary

TM14A serves as an important component in cellular transport mechanisms that involve modulation of ion channels. Studies indicate that TM14A is part of a larger protein complex required for these activities. The activity of TM14A influences the movement of ions across the cell membrane affecting cellular homeostasis and communication. It interacts with other membrane proteins facilitating effective signal transduction.

Pathways

TM14A contributes significantly to the Wnt signaling pathway and the MAPK/ERK pathway. Within the Wnt pathway TM14A works alongside proteins like β-catenin to regulate gene expression linked to cell fate determination. In the MAPK/ERK pathway TM14A interacts with proteins such as Ras and Raf facilitating cellular responses to external growth factors. These pathways are essential for controlling various cellular processes like proliferation and differentiation.

Alterations in TM14A expression or function have been associated with colon cancer and cystic fibrosis. In colon cancer TM14A involves dysfunction at a molecular level where it dysregulates the Wnt signaling pathway. This aberration can lead to uncontrolled cellular growth contributing to tumorigenesis. In cystic fibrosis TM14A may have associations with the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein influencing ion transport abnormalities characteristic of the disorder. Understanding TM14A's role in these diseases offers potential therapeutic targets for intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
See full target information TMEM14A
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 24:614 PubMed36160886

2022

TMEM14A aggravates the progression of human ovarian cancer cells by enhancing the activity of glycolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Qingmei Zhang,Xiaohong Wang,Xuan Zhang,Jingfen Zhan,Binbin Zhang,Jin Jia,Jie Chen

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35:e21948 PubMed34569098

2021

A non-translational role of threonyl-tRNA synthetase in regulating JNK signaling during myogenic differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Chong Dai,Adriana Reyes-Ordoñez,Jae-Sung You,Jie Chen
View all publications
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Product promise

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