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AB230876

Anti-TM2D1/BBP antibody

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(1 Publication)

Rabbit Polyclonal TM2D1/BBP antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TM2D1 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

BBP, TM2D1, TM2 domain-containing protein 1, Amyloid-beta-binding protein, hBBP

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM2D1/BBP antibody (AB230876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM2D1/BBP antibody (AB230876)

Formalin-fixed, paraffin-embedded human testis tissue stained for TM2D1/BBP using ab230876 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-TM2D1/BBP antibody (AB230876)
  • WB

Supplier Data

Western blot - Anti-TM2D1/BBP antibody (AB230876)

All lanes:

Western blot - Anti-TM2D1/BBP antibody (ab230876) at 1/500 dilution

Lane 1:

MCF7 (Human breast adenocarcinoma cell line) whole cell lysate

Lane 2:

Mouse kidney lysate

Predicted band size: 22 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM2D1/BBP antibody (AB230876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM2D1/BBP antibody (AB230876)

Formalin-fixed, paraffin-embedded human brain cortex tissue stained for TM2D1/BBP using ab230876 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human TM2D1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9BX74

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.01% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TM2D1 protein often called BBP is an important target encoded by the TM2D1 gene. Its molecular weight is approximately 26 kDa. Expression of TM2D1 occurs across several tissues with significant levels noted in the brain. The protein localizes to cellular membranes suggesting involvement in membrane-associated processes. TM2D1 participates in molecular interactions that are essential for proper cellular functioning and signaling.
Biological function summary

TM2D1 is involved in neurodevelopmental processes and cellular communication. It does not function in isolation but as part of a protein complex influencing neurogenesis and synaptic organization. Its actions impact signaling pathways that regulate the development and function of neural tissues. TM2D1's role in these processes points to its significance in maintaining neural integrity and function.

Pathways

TM2D1 interacts in pathways involving proteins like Notch which is essential in neurodevelopment and cellular differentiation. The Notch signaling pathway has a critical influence on cell fate decisions and TM2D1 helps modulate these processes ensuring proper neural development. Another pathway of interest may include those influencing synaptic organization underlining TM2D1's involvement in more specialized neural processes.

TM2D1 has been associated with neurodegenerative conditions such as Alzheimer's disease and Rett syndrome. In Alzheimer's disease TM2D1 may impact amyloid precursor protein processing indirectly linking it to amyloid-beta accumulation. In Rett syndrome a connection might exist with MECP2 another protein involved in neuronal development and function. These associations highlight TM2D1's relevance in neuropathological conditions where its normal function is disrupted leading to disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.
See full target information TM2D1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nutrition & diabetes 12:23 PubMed35443706

2022

Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Tongtong Qiu,Xin Yang,Jingzhou Wang,Chongge Pan,Xiaolong Chu,Jianyu Xiong,Jianxin Xie,Yongsheng Chang,Cuizhe Wang,Jun Zhang
View all publications
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