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AB246013

Anti-TM2D3 antibody

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(1 Publication)

Rabbit Polyclonal TM2D3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TM2D3 aa 50-150.

View Alternative Names

BLP2, TM2D3, TM2 domain-containing protein 3, Beta-amyloid-binding protein-like protein 2, BBP-like protein 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM2D3 antibody (AB246013)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM2D3 antibody (AB246013)

Paraffin-embedded human stomach (lower) tissue stained for TM2D3 using ab246013 at 1/200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-TM2D3 antibody (AB246013)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TM2D3 antibody (AB246013)

PFA-fixed, Triton X-100 permeabilized HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for TM2D3 (green) using ab246013 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TM2D3 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q9BRN9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TM2D3 also known as BRI3BP is a transmembrane protein with a mass of approximately 37 kDa. It is expressed in various tissues including the brain heart and skeletal muscle. TM2D3 is embedded in cellular membranes and is thought to participate in molecular signaling. It interacts with other proteins through its transmembrane domains and contributes to signal transduction pathways.
Biological function summary

TM2D3 has roles in cellular communication and regulation. It is part of a protein complex involved in modulating cellular responses to external stimuli. TM2D3 may affect processes such as cell adhesion and migration by interacting with other membrane proteins influencing cellular dynamics. Researchers continue to determine exact biological mechanisms due to its significant presence in critical tissues.

Pathways

TM2D3 integrates into the Notch signaling pathway an important pathway for cell differentiation and proliferation. Its interaction with the Notch receptor and related components influences developmental processes. Additionally TM2D3 has connections with the MAPK signaling pathway where it may modulate responses to growth factors through interactions with proteins like MEK and ERK.

TM2D3 shows relevance to Alzheimer's disease and cancer. Studies suggest that TM2D3 may interact with APP (Amyloid precursor protein) related to Alzheimer's disease affecting amyloid plaque formation. In cancer alterations in TM2D3 expression have links with tumor progression possibly involving interactions with proteins like beta-catenin that can influence cell cycle regulation and metastasis. Ongoing research aims to clarify these associations and their implications for therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable positive regulator of Notch signaling.
See full target information TM2D3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Environmental toxicology 39:1989-2005 PubMed38088504

2023

OTU deubiquitinase 7B facilitates the hyperthermia-induced inhibition of lung cancer progression through enhancing Smac-mediated mitochondrial dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Sun,Jun Bai,Jingying Sun,Yang Sun,Fan Zhang,He Li,Ying Liu,Lian Meng,Xifang Wang
View all publications
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Complementary Products

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AB164224

Recombinant Human TM2D3 protein

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