Rabbit Polyclonal TM2D3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TM2D3 aa 50-150.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human TM2D3 aa 50-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BRN9
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
Alternative names
BLP2, TM2D3, TM2 domain-containing protein 3, Beta-amyloid-binding protein-like protein 2, BBP-like protein 2
Recommended products
Rabbit Polyclonal TM2D3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TM2D3 aa 50-150.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human TM2D3 aa 50-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BRN9
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TM2D3 also known as BRI3BP is a transmembrane protein with a mass of approximately 37 kDa. It is expressed in various tissues including the brain heart and skeletal muscle. TM2D3 is embedded in cellular membranes and is thought to participate in molecular signaling. It interacts with other proteins through its transmembrane domains and contributes to signal transduction pathways.
- Biological function summary
TM2D3 has roles in cellular communication and regulation. It is part of a protein complex involved in modulating cellular responses to external stimuli. TM2D3 may affect processes such as cell adhesion and migration by interacting with other membrane proteins influencing cellular dynamics. Researchers continue to determine exact biological mechanisms due to its significant presence in critical tissues.
- Pathways
TM2D3 integrates into the Notch signaling pathway an important pathway for cell differentiation and proliferation. Its interaction with the Notch receptor and related components influences developmental processes. Additionally TM2D3 has connections with the MAPK signaling pathway where it may modulate responses to growth factors through interactions with proteins like MEK and ERK.
- Associated diseases and disorders
TM2D3 shows relevance to Alzheimer's disease and cancer. Studies suggest that TM2D3 may interact with APP (Amyloid precursor protein) related to Alzheimer's disease affecting amyloid plaque formation. In cancer alterations in TM2D3 expression have links with tumor progression possibly involving interactions with proteins like beta-catenin that can influence cell cycle regulation and metastasis. Ongoing research aims to clarify these associations and their implications for therapeutic strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM2D3 antibody (ab246013)
Paraffin-embedded human stomach (lower) tissue stained for TM2D3 using ab246013 at 1/200 dilution in immunohistochemical analysis.
Immunocytochemistry/ Immunofluorescence - Anti-TM2D3 antibody (ab246013)
PFA-fixed, Triton X-100 permeabilized HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for TM2D3 (green) using ab246013 at 4 μg/ml in ICC/IF.
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