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AB169629

Anti-TM6SF2 antibody

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(1 Publication)

Mouse Polyclonal TM6SF2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Transmembrane 6 superfamily member 2.

View Alternative Names

Transmembrane 6 superfamily member 2, TM6SF2

1 Images
Western blot - Anti-TM6SF2 antibody (AB169629)
  • WB

Unknown

Western blot - Anti-TM6SF2 antibody (AB169629)

All lanes:

Western blot - Anti-TM6SF2 antibody (ab169629) at 1 µg/mL

Lane 1:

TM6SF2 transfected 293T cell lysate at 15 µL

Lane 2:

293T cell lysate at 15 µL

Secondary

All lanes:

Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

Predicted band size: 34 kDa,43 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Transmembrane 6 superfamily member 2.

Q9BZW4

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Alternative Products

Primary Antibodies

AB244532

Anti-TM6SF2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM6SF2 antibody (AB244532)

  • 0
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Complementary Products

Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

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Primary Antibodies

AB234744

Anti-YME1L1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-YME1L1 antibody (AB234744)

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Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

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Primary Antibodies

AB137043

Anti-HMGCS2 antibody [EPR8642]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGCS2 antibody [EPR8642] (AB137043)

  • 5
  • 7
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TM6SF2 also known as Transmembrane 6 Superfamily Member 2 is a protein involved in lipid metabolism. It has a mass of approximately 42 kDa. TM6SF2 expresses mainly in the liver and to a lesser extent in the small intestine. It plays a mechanical role in modulating triglyceride metabolism by affecting very-low-density lipoprotein (VLDL) secretion from the liver. TM6SF2 influences the steady-state levels of triglycerides in hepatocytes by promoting the degradation of triglycerides within the endoplasmic reticulum.
Biological function summary

TM6SF2 impacts lipid and energy homeostasis. It does not form part of a large protein complex but it has an independent role in cellular metabolism. The modulation of VLDL secretion by TM6SF2 helps maintain appropriate lipid levels in circulation contributing to overall metabolic health. It exhibits structural aspects that allow it to interact with other molecules within the cellular lipid landscape influencing cholesterol homeostasis as well.

Pathways

TM6SF2 is involved in the lipid metabolism and energy homeostasis pathways. It interacts with other proteins like APOE and LPCAT1 to regulate lipid levels within these pathways. TM6SF2 acts as an important modulator by affecting lipid processing and sequestration. The regulation of these pathways ensures balanced lipid concentrations which is essential for normal cellular and systemic functions.

TM6SF2 associates with non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. A mutation in TM6SF2 can increase susceptibility to NAFLD by causing inefficient hepatic lipid processing. This mutation known as E167K links TM6SF2 to accumulation of fat in the liver. TM6SF2 also connects with proteins like APOB through the influence on lipid levels contributing to cardiovascular risk. Understanding its role offers potential for targeting these diseases therapeutically.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed : 24531328, PubMed : 24927523). May function as sterol isomerase (PubMed : 25566323).
See full target information Transmembrane 6 superfamily member 2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of physiological anthropology 39:32 PubMed33028417

2020

NOD-like receptors mediate inflammatory lung injury during plateau hypoxia exposure.

Applications

Unspecified application

Species

Unspecified reactive species

Haiyan Wang,Xue Lin,Xiaoyan Pu
View all publications
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Product promise

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