AB244532

Anti-TM6SF2 antibody

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(1 Publication)

Rabbit Polyclonal TM6SF2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transmembrane 6 superfamily member 2 aa 200-300.

View Alternative Names

Transmembrane 6 superfamily member 2, TM6SF2

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM6SF2 antibody (AB244532)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM6SF2 antibody (AB244532)

Paraffin-embedded human fallopian tube tissue stained for TM6SF2 using ab244532 at 1/20 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Transmembrane 6 superfamily member 2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

Q9BZW4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TM6SF2 also known as Transmembrane 6 Superfamily Member 2 is a protein involved in lipid metabolism. It has a mass of approximately 42 kDa. TM6SF2 expresses mainly in the liver and to a lesser extent in the small intestine. It plays a mechanical role in modulating triglyceride metabolism by affecting very-low-density lipoprotein (VLDL) secretion from the liver. TM6SF2 influences the steady-state levels of triglycerides in hepatocytes by promoting the degradation of triglycerides within the endoplasmic reticulum.

Biological function summary

TM6SF2 impacts lipid and energy homeostasis. It does not form part of a large protein complex but it has an independent role in cellular metabolism. The modulation of VLDL secretion by TM6SF2 helps maintain appropriate lipid levels in circulation contributing to overall metabolic health. It exhibits structural aspects that allow it to interact with other molecules within the cellular lipid landscape influencing cholesterol homeostasis as well.

Pathways

TM6SF2 is involved in the lipid metabolism and energy homeostasis pathways. It interacts with other proteins like APOE and LPCAT1 to regulate lipid levels within these pathways. TM6SF2 acts as an important modulator by affecting lipid processing and sequestration. The regulation of these pathways ensures balanced lipid concentrations which is essential for normal cellular and systemic functions.

TM6SF2 associates with non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. A mutation in TM6SF2 can increase susceptibility to NAFLD by causing inefficient hepatic lipid processing. This mutation known as E167K links TM6SF2 to accumulation of fat in the liver. TM6SF2 also connects with proteins like APOB through the influence on lipid levels contributing to cardiovascular risk. Understanding its role offers potential for targeting these diseases therapeutically.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed : 24531328, PubMed : 24927523). May function as sterol isomerase (PubMed : 25566323).

See full target information Transmembrane 6 superfamily member 2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1618012 PubMed40821844

2025

CRIF1 gene therapy ameliorates inflammatory bowel disease by suppressing TH17 cells and fibrosis through mitochondrial function regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Jin-Sil Park,Hye Yeon Kang,Ha Yeon Jeong,SeungCheon Yang,JeongWon Choi,Sang Hee Cho,Sol Kim,Bo-In Lee,Mi-La Cho

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TM6SF2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TM6SF2 antibody (AB244532)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise