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AB154581

Anti-TMCO3 antibody

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(1 Publication)

Rabbit Polyclonal TMCO3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMCO3 aa 50-350.

View Alternative Names

C13orf11, TMCO3, UNQ2419/PRO4976, Solute carrier family 9 member D1, Putative LAG1-interacting protein, Transmembrane and coiled-coil domain-containing protein 3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMCO3 antibody (AB154581)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMCO3 antibody (AB154581)

Immunohistochemical analysis of paraffin-embedded U87 xenograft, labelling TMCO3 using ab154581 at 1/500.

Western blot - Anti-TMCO3 antibody (AB154581)
  • WB

Unknown

Western blot - Anti-TMCO3 antibody (AB154581)

7.5% SDS PAGE

All lanes:

Western blot - Anti-TMCO3 antibody (ab154581) at 1/10000 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 76 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TMCO3 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.

Q6UWJ1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/20000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMCO3 also known as Transmembrane and Coiled-Coil Domains Protein 3 is a protein with a mass of approximately 81 kDa. It plays a role in ion homeostasis involved with transporting ions across cell membranes. TMCO3 contains transmembrane domains which enable its function as a channel or transporter. The protein is expressed in various tissues with abundant expression in the kidney and lung. Its transmembrane topology suggests its importance in maintaining cellular ion balance.
Biological function summary

TMCO3 participates in maintaining ion concentrations in cells. This protein does not currently have a fully described complex that it forms part of but its role is consistent with other membrane transport proteins. TMCO3 acts in connection with ion gradients implying a function in cellular processes tied to ionic changes such as cellular volume regulation and signal transduction.

Pathways

TMCO3 connects closely to the ion transport pathway which is important for maintaining the electrochemical gradients across membranes. This pathway influences various cellular activities including nerve impulse transmission and muscle contraction. TMCO3 may potentially interact with other ion transport proteins like the sodium-potassium pump (Na+/K+-ATPase) forming a network within the cellular ion management system.

TMCO3 has potential links to renal tubular disorders and pulmonary conditions where ion transport malfunction plays a part. Abnormalities in ion homeostasis can lead to these conditions suggesting a possible diagnostic role for TMCO3. It may interact with other proteins such as the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) known to be associated with ion transport issues in cystic fibrosis and other diseases related to ion balance disruption.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable Na(+) : H(+) or K(+) : H(+) antiporter (Probable). Upon IGF1-dependent phosphorylation, facilitates the membrane translocation and activation of AKT1 (PubMed : 40285646).
See full target information TMCO3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 6:31021 PubMed27484837

2016

Mutations in the TMCO3 Gene are Associated with Cornea Guttata and Anterior Polar Cataract.

Applications

ICC/IF

Species

Unspecified reactive species

Peng Chen,Xiaodan Hao,Wenfeng Li,Xiaowen Zhao,Yusen Huang
View all publications
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Product promise

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