Anti-TMED7 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TMED7 also known as Transmembrane emp24 domain-containing protein 7 is a member of the p24 protein family involved in the vesicular trafficking process. It has a molecular mass of approximately 24 kDa. TMED7 is typically expressed in the endoplasmic reticulum and Golgi apparatus. It has an important role in maintaining the structure and function of these organelles by helping facilitate the transport of proteins between these two cellular compartments.

Biological function summary

TMED7 is a component of the coat protein complex I (COPI) vesicular transport mechanism. It participates in retrograde transport which is essential for recycling Golgi-resident enzymes back to the endoplasmic reticulum. This protein acts by recognizing specific cargo molecules that need to be transported associating with the COPI complex to move these loads in the retrograde direction.

Pathways

The TMED7 protein is actively involved in the secretory pathway and protein trafficking. It plays a part in the Golgi to endoplasmic reticulum transport alongside proteins like TMED9 that also associate with COPI vesicles. This involvement is important for ensuring a balanced protein distribution and proper cellular function influencing processes such as protein folding and modification.

Associated diseases and disorders

TMED7 connects to conditions impacting the trafficking machinery like congenital disorders of glycosylation. Aberrations in TMED7 and related proteins such as TMED10 can disrupt the normal intracellular transport pathway leading to protein mislocalization and functional deficiencies. It also has implications in immune system disorders as changes in its pathway can affect the secretion of cytokines which play a role in inflammatory responses.