Rabbit Polyclonal TMEM107 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TMEM107.
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Publications
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- Thoracic cancer 12:79-892020TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHuihui Xu,Song Dun,Ying Gao,Jian Ming,Linping Hui,Xueshan QiuPubMed 33124203
- Nature genetics 48:1185-922016Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmma M Jenkinson et. al.PubMed 27571260
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TMEM107. The exact immunogen used to generate this antibody is proprietary information. Database link Q6UX40
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5.00000-20.00000 µg/mL | Notes - |
Target data
Function
Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474).
Alternative names
DC20, UNQ638/PRO1268, TMEM107, Transmembrane protein 107
Recommended products
Rabbit Polyclonal TMEM107 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TMEM107.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TMEM107. The exact immunogen used to generate this antibody is proprietary information. Database link Q6UX40
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TMEM107 also known as Transmembrane Protein 107 is a cell membrane protein involved in ciliary function and development. It weighs approximately 15 kDa. TMEM107 localizes to the ciliary transition zone a critical region within cilia. Expressed in many tissues including the brain heart and kidneys TMEM107 plays a mechanical role in regulating ciliary structure and signaling by acting as a scaffold or anchor for other proteins in the cilia.
- Biological function summary
TMEM107 contributes significant roles in cilium-related processes essential for cellular signaling and development. It forms part of a protein complex within the ciliary transition zone which regulates the entry and exit of molecular components in the cilia. By participating in this complex TMEM107 ensures the proper functioning of cilia which is necessary for maintaining cellular signaling pathways critical for organ development.
- Pathways
TMEM107 links to ciliogenesis and Sonic Hedgehog (SHH) signaling pathways. These pathways play important roles in embryogenesis and the development of various organs. TMEM107 function related to the Sonic Hedgehog signaling involves its interaction with proteins such as Gli2 and RPGRIP1L which are important for the signal transduction and regulation of gene expression during cell differentiation and tissue patterning.
- Associated diseases and disorders
Disruptions in TMEM107 are associated with ciliopathies like Meckel-Gruber syndrome and Joubert syndrome which are congenital disorders affecting organs development and function. TMEM107 mutations lead to impaired cilia function and contribute to these disorders. The connection between TMEM107 and proteins like MKS1 and CEP290 emphasizes its relevance in understanding the molecular pathways of these diseases and provides possible targets for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-TMEM107 antibody - N-terminal (ab181396)
All lanes: Western blot - Anti-TMEM107 antibody - N-terminal (ab181396) at 1 µg/mL
Lane 1: THP-1 cell lysate at 15 µg
Lane 2: THP-1 cell lysate at 15 µg with immunizing peptide
Predicted band size: 16 kDa
Observed band size: 19 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM107 antibody - N-terminal (ab181396)
Immunohistochemical analysis of paraffin-embedded Human lymph node tissue labeling TMEM107 with ab181396 at 5 μg/ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM107 antibody - N-terminal (ab181396)
Immunohistochemical analysis of paraffin-embedded Human lymph node tissue labeling TMEM107 with ab181396 at 20 μg/ml.
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