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AB167096

Anti-TMEM135 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal TMEM135 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMEM135.

View Alternative Names

Transmembrane protein 135, Peroxisomal membrane protein 52, PMP52, TMEM135

1 Images
Western blot - Anti-TMEM135 antibody - C-terminal (AB167096)
  • WB

Unknown

Western blot - Anti-TMEM135 antibody - C-terminal (AB167096)

Lane 1:

Western blot - Anti-TMEM135 antibody - C-terminal (ab167096) at 1 µg/mL

Lane 2:

Western blot - Anti-TMEM135 antibody - C-terminal (ab167096) at 2 µg/mL

All lanes:

Rat liver tissue lysate at 15 µg

Predicted band size: 52 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TMEM135. The exact immunogen used to generate this antibody is proprietary information.

Q86UB9

Specificity

At least two isoforms of TMEM135 are known to exist; ab167096 will detect both isoforms.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM135 also known as Transmembrane Protein 135 has a molecular mass of approximately 50 kDa. This protein is expressed in multiple tissues with high levels found in adipose tissue and heart. It functions mechanically by regulating lipid metabolism and its activity is associated with mitochondria. TMEM135 helps maintain mitochondrial dynamics including fusion and fission processes which are critical for proper energy homeostasis in cells.
Biological function summary

TMEM135 participates in energy balance and lipid metabolism. This protein does not function alone; it is part of complexes involving mitochondrial membranes. Within these complexes TMEM135 helps orchestrate the metabolism of lipids impacting overall energy distribution in cells. Its role extends to regulating oxidative stress suggesting it plays a part in cellular responses to metabolic changes.

Pathways

TMEM135 functions contribute to the mitochondrial apoptosis pathway and the peroxisome proliferator-activated receptor (PPAR) signaling pathway. These pathways are essential in controlling cell viability and energy metabolism respectively. TMEM135 interacts with proteins like DRP1 and PGC-1α which further help in mitochondrial division and energy metabolism regulation reflecting its importance in cellular energetics.

TMEM135 displays implications in metabolic syndrome and cardiovascular disease. Its influence on lipid metabolism and mitochondrial function links it to these conditions. In metabolic syndrome altered function of TMEM135 may affect PGC-1α involved in the regulation of glucose and lipid homeostasis. In cardiovascular disease disrupted mitochondrial dynamics due to TMEM135 dysfunction can lead DRP1-driven imbalances resulting in compromised heart function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.
See full target information TMEM135
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:1506 PubMed39929829

2025

Enzymatic conversion of blood group B kidney prevents hyperacute antibody-mediated injuries in ABO-incompatible transplantation.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Zeng,Ming Ma,Xiaojuan Jiang,Zhengsheng Rao,Dan Huang,Hao Zhang,Saifu Yin,Rong Bao,Haohan Zhang,Zhiling Wang,Hongwei Gao,Feng Gong,Tao Lin,Keqin Zhang,Turun Song
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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