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AB193198

Anti-TMEM14B antibody

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(1 Publication)

Rabbit Polyclonal TMEM14B antibody. Suitable for ICC, WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TMEM14B.

View Alternative Names

Transmembrane protein 14B, TMEM14B

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM14B antibody (AB193198)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM14B antibody (AB193198)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of formalin-fixed, paraffin-embedded human kidney tissue labeling TMEM14B with ab193198 at a 1/100 dilution.

Immunocytochemistry - Anti-TMEM14B antibody (AB193198)
  • ICC

Supplier Data

Immunocytochemistry - Anti-TMEM14B antibody (AB193198)

Immunocytochemistry analysis of HepG2 (Human liver hepatocellular carcinoma cell line) cells labeling TMEM14B with ab193198 at a 1/100 dilution, followed by an Alexa Fluor® 488-conjugated Goat anti-Rabbit IgG (H&L).

Western blot - Anti-TMEM14B antibody (AB193198)
  • WB

Supplier Data

Western blot - Anti-TMEM14B antibody (AB193198)

Western blot analysis of K562 cell lysate labeling TMEM14B with ab193198 at 2 ug/ml.

All lanes:

Western blot - Anti-TMEM14B antibody (ab193198) at 2 µg/mL

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 12 kDa

Observed band size: 13 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TMEM14B.

Q9NUH8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
>95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM14B also known as Transmembrane Protein 14B is a mitochondrial inner membrane protein with a molecular weight of approximately 15 kDa. It is involved in the transport of molecules across the mitochondrial membranes. TMEM14B is expressed in a variety of tissues with a significant presence in the respiratory and nervous systems. The protein comprises several transmembrane helices playing an important role in maintaining mitochondrial function.
Biological function summary

TMEM14B is key for mitochondrial biogenesis and the regulation of cellular energy metabolism. It is an integral component of the mitochondrial complex and contributes to the proper assembly of respiratory chain complexes. This protein facilitates the import of other essential proteins into the mitochondrial matrix ensuring efficient mitochondrial function and cellular energy homeostasis. Its activity is closely associated with energy production and apoptosis pathways.

Pathways

TMEM14B has essential roles in the oxidative phosphorylation and apoptosis pathways. These pathways are vital for energy production and programmed cell death respectively. TMEM14B's interaction with cytochrome c oxidase and caspases highlights its involvement in mitochondrial respiration and apoptotic regulation. Through these pathways TMEM14B collaborates with other mitochondrial proteins such as ATP synthase to support cellular energetic processes.

TMEM14B's dysfunction is linked to neurodegenerative disorders and metabolic syndromes. Its improper functioning may lead to impaired mitochondrial activity contributing to conditions like Alzheimer's disease and metabolic syndrome. The protein relation with cytochrome c in these disorders highlights TMEM14B's involvement in neuronal cell death and metabolic dysregulation. Understanding TMEM14B's role in these diseases can provide insights into potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.
See full target information TMEM14B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 12:24033-24056 PubMed33221762

2020

lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Wang,Zhi-Jie Zhao,Xue-Ran Kang,Tao Bian,Zhe-Min Shen,Yang Jiang,Bao Sun,Han-Bing Hu,Yi-Sheng Chen
View all publications
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Product promise

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