AB213691

Anti-TMEM158 antibody

Name: Anti-TMEM158 antibody (ab213691) | Abcam
Brand: Abcam Limited
SKU: AB213691

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(1 Publication)

Rabbit Polyclonal TMEM158 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMEM158 aa 200-250 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

HBBP, RIS1, TMEM158, Transmembrane protein 158, 40 kDa BINP-binding protein, Ras-induced senescence protein 1, p40BBP

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (AB213691)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (AB213691)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat brain tissue labeling TMEM158 with ab213691 at 1/200 dilution, ollowed by a conjugated secondary and DAPI staining. Antigen retrieval method used boiling in sodium citrate buffer.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (AB213691)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat brain tissue labeling TMEM158 with ab213691 at 1/200 dilution, followed by a conjugated secondary and DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (AB213691)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat brain tissue labeling TMEM158 with ab213691 at 1/200 dilution, followed by a conjugated secondary and DAB staining. Antigen retrieval method used boiling in sodium citrate buffer.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TMEM158 aa 200-250 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8WZ71

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>When using a fluorescent probe the recommended dilution is 1/50 – 1/200.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM158 also known as RERG (Ras-related estrogen-regulated growth inhibitor) is a protein that weighs approximately 23 kDa. It is a transmembrane protein often found expressed in various tissues with significant expression noted in the brain and breast tissue. TMEM158 plays a role in cell signaling by functioning as a modulator within the membrane. Its presence in these tissues indicates a role in regulating cellular responses to external stimuli acting as a part of the cellular signaling machinery.

Biological function summary

TMEM158 influences several growth-related processes. It does not form part of a large protein complex but rather acts independently to influence cell population proliferation. TMEM158's activity can affect cellular responses to hormonal changes especially in tissues that are sensitive to estrogen. By interacting with cellular growth signals it has a regulatory effect on pathways that control cell division and growth suggesting its potential involvement in controlling tumor progression in estrogen-sensitive tissues.

Pathways

TMEM158 plays a role in the MAPK (mitogen-activated protein kinase) signaling pathway. This pathway is vital for cell growth and division and TMEM158's modulation can influence how cells respond to external mitogenic signals. In this context proteins such as ERK1/2 (extracellular signal-regulated kinases) interact with TMEM158 affecting signal transduction and potentially altering downstream effects such as gene expression and cellular survival.

TMEM158 has been connected to breast cancer due to its involvement in estrogen signaling and cell proliferation. Estrogen receptor-positive breast cancer exhibits altered TMEM158 expression patterns. Connections to proteins such as the estrogen receptor (ER) link TMEM158 to cancer-related pathways. Besides cancer aberrant expression of TMEM158 has implications in neurological disorders where its expression in brain tissue suggests potential roles in neurodegenerative diseases although this area requires further research to clarify its impact.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.

See full target information TMEM158

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Clinical epigenetics 17:166 PubMed41044679

2025

Identification of methylation-related genes and the potential regulatory mechanism of SLAMF6 in CMS4 colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Liu,Jiyuan Yang,Chunmei Zhao,Guihua Wang,Renfei Lu,Xudong Wang

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-TMEM158 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (AB213691)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (AB213691)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (AB213691)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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