Rabbit Polyclonal TMEM158 antibody. Suitable for IHC-P and reacts with Rat samples. Immunogen corresponding to Synthetic Peptide within Human TMEM158 aa 200-250 conjugated to Keyhole Limpet Haemocyanin.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TMEM158 aa 200-250 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q8WZ71
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Predicted |
| Mouse | Predicted |
| Rat | Tested |
| Cow | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/100.00000 - 1/500.00000 | Notes When using a fluorescent probe the recommended dilution is 1/50 – 1/200. Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Cow, Human | Dilution info - | Notes - |
Target data
Function
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
Alternative names
HBBP, RIS1, TMEM158, Transmembrane protein 158, 40 kDa BINP-binding protein, Ras-induced senescence protein 1, p40BBP
Recommended products
Rabbit Polyclonal TMEM158 antibody. Suitable for IHC-P and reacts with Rat samples. Immunogen corresponding to Synthetic Peptide within Human TMEM158 aa 200-250 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TMEM158 aa 200-250 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q8WZ71
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TMEM158 also known as RERG (Ras-related estrogen-regulated growth inhibitor) is a protein that weighs approximately 23 kDa. It is a transmembrane protein often found expressed in various tissues with significant expression noted in the brain and breast tissue. TMEM158 plays a role in cell signaling by functioning as a modulator within the membrane. Its presence in these tissues indicates a role in regulating cellular responses to external stimuli acting as a part of the cellular signaling machinery.
- Biological function summary
TMEM158 influences several growth-related processes. It does not form part of a large protein complex but rather acts independently to influence cell population proliferation. TMEM158's activity can affect cellular responses to hormonal changes especially in tissues that are sensitive to estrogen. By interacting with cellular growth signals it has a regulatory effect on pathways that control cell division and growth suggesting its potential involvement in controlling tumor progression in estrogen-sensitive tissues.
- Pathways
TMEM158 plays a role in the MAPK (mitogen-activated protein kinase) signaling pathway. This pathway is vital for cell growth and division and TMEM158's modulation can influence how cells respond to external mitogenic signals. In this context proteins such as ERK1/2 (extracellular signal-regulated kinases) interact with TMEM158 affecting signal transduction and potentially altering downstream effects such as gene expression and cellular survival.
- Associated diseases and disorders
TMEM158 has been connected to breast cancer due to its involvement in estrogen signaling and cell proliferation. Estrogen receptor-positive breast cancer exhibits altered TMEM158 expression patterns. Connections to proteins such as the estrogen receptor (ER) link TMEM158 to cancer-related pathways. Besides cancer aberrant expression of TMEM158 has implications in neurological disorders where its expression in brain tissue suggests potential roles in neurodegenerative diseases although this area requires further research to clarify its impact.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (ab213691)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat brain tissue labeling TMEM158 with ab213691 at 1/200 dilution, ollowed by a conjugated secondary and DAPI staining. Antigen retrieval method used boiling in sodium citrate buffer.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (ab213691)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat brain tissue labeling TMEM158 with ab213691 at 1/200 dilution, followed by a conjugated secondary and DAB staining. Antigen retrieval method used boiling in sodium citrate buffer.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM158 antibody (ab213691)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat brain tissue labeling TMEM158 with ab213691 at 1/200 dilution, followed by a conjugated secondary and DAB staining.
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