AB237533

Anti-TMEM161A antibody

Name: Anti-TMEM161A antibody (ab237533) | Abcam
Brand: Abcam Limited
SKU: AB237533

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(1 Publication)

Rabbit Polyclonal TMEM161A antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM161A aa 1-100.

View Alternative Names

UNQ582/PRO1152, TMEM161A, Transmembrane protein 161A, Adaptive response to oxidative stress protein 29, AROS-29

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-TMEM161A antibody (AB237533)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TMEM161A antibody (AB237533)

PC-3 (human prostate adenocarcinoma cell line) cells stained for TMEM161A (green) using ab237533 at a 1/100 dilution in ICC/IF. Secondary used is an Alexa-Fluor^®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM161A antibody (AB237533)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM161A antibody (AB237533)

Paraffin-embedded human endometrial cancer tissue stained for TMEM161A with ab237533 at a 1/500 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Supplier Data

Western blot - Anti-TMEM161A antibody (AB237533)

All lanes:

Western blot - Anti-TMEM161A antibody (ab237533) at 1/500 dilution

All lanes:

Rat liver tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 53 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TMEM161A aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9NX61

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/500", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity greater than 95%

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM161A also known as Transmembrane Protein 161A is a member of the larger transmembrane protein family. Structurally TMEM161A is characterized by multiple transmembrane domains. Its mass is approximately 55 kDa. Researchers have observed its expression in various tissues including the brain and kidney. The exact mechanical role is not fully elucidated but it is suggested to play a role in cellular communication through its membrane localization.

Biological function summary

TMEM161A contributes to cellular processes involving intercellular signaling and ion transport. Although scientists have not yet identified a specific complex that includes TMEM161A its function as a transmembrane protein implies potential involvement in forming channels or receptors. These elements are important for maintaining ionic balances and signaling pathways inside cells indicating TMEM161A as a supportive component in these processes.

Pathways

Recent findings indicate TMEM161A's potential involvement in cell signaling and transport pathways. An important pathway that features TMEM161A activity includes signal transduction where it may interact with proteins like ion channels such as voltage-gated channels. These interactions suggest TMEM161A could modulate responses to cellular environment changes linking it to broader cellular response mechanisms.

Scientists have noted potential links between TMEM161A and neurological disorders. Some studies suggest its involvement in conditions like epilepsy where abnormal ion transport plays a significant role. Alterations in TMEM161A expression might impact channel proteins such as voltage gated potassium channels which are important for maintaining action potentials in neurons potentially exacerbating these conditions. Research continues to explore TMEM161A's full role in these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.

See full target information TMEM161A

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

OncoTargets and therapy 14:1007-1020 PubMed33603407

2021

Tandem Mass Tag-Based Proteomic Analysis of Potential Biomarkers for Hepatocellular Carcinoma Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wang,Qiang Li,Ge Huang,Bing-Yao Lin,Dongzi Lin,Yan Ma,Zhao Zhang,Tao Chen,Jie Zhou

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TMEM161A antibody

Immunocytochemistry/ Immunofluorescence - Anti-TMEM161A antibody (AB237533)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM161A antibody (AB237533)

Western blot - Anti-TMEM161A antibody (AB237533)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise