AB180954

Anti-TMEM161A antibody [EPR14369]

RabMAb
Recombinant
What is this?

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(2 Publications)

Rabbit Recombinant Monoclonal TMEM161A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications.

View Alternative Names

UNQ582/PRO1152, TMEM161A, Transmembrane protein 161A, Adaptive response to oxidative stress protein 29, AROS-29

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM161A antibody [EPR14369] (AB180954)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM161A antibody [EPR14369] (AB180954)

Immunohistochemical analysis of paraffin-embedded Human infiltrating duct carcinoma of breast tissue labeling TMEM161A with ab180954 at 1/100 dilution followed by prediluted ImmunoHistoprobe (Ready to use) HRP Polymer for Rabbit IgG. Counterstained with Hematoxylin.

Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM161A antibody [EPR14369] (AB180954)

Immunohistochemical analysis of paraffin-embedded Human lung adenocarcinoma tissue labeling TMEM161A with ab180954 at 1/100 dilution followed by prediluted ImmunoHistoprobe (Ready to use) HRP Polymer for Rabbit IgG. Counterstained with Hematoxylin.

Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.

Supplier Data

Western blot - Anti-TMEM161A antibody [EPR14369] (AB180954)

All lanes:

Western blot - Anti-TMEM161A antibody [EPR14369] (ab180954) at 1/100000 dilution

Lane 1:

HT1080 cell lysate at 20 µg

Lane 2:

HepG2 cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Predicted band size: 51 kDa,53 kDa

Observed band size: 54 kDa,66 kDa

false

Supplier Data

Western blot - Anti-TMEM161A antibody [EPR14369] (AB180954)

All lanes:

Western blot - Anti-TMEM161A antibody [EPR14369] (ab180954) at 1/20000 dilution

All lanes:

Human fetal liver tissue lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 53 kDa

Observed band size: 54 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR14369

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM161A also known as Transmembrane Protein 161A is a member of the larger transmembrane protein family. Structurally TMEM161A is characterized by multiple transmembrane domains. Its mass is approximately 55 kDa. Researchers have observed its expression in various tissues including the brain and kidney. The exact mechanical role is not fully elucidated but it is suggested to play a role in cellular communication through its membrane localization.

Biological function summary

TMEM161A contributes to cellular processes involving intercellular signaling and ion transport. Although scientists have not yet identified a specific complex that includes TMEM161A its function as a transmembrane protein implies potential involvement in forming channels or receptors. These elements are important for maintaining ionic balances and signaling pathways inside cells indicating TMEM161A as a supportive component in these processes.

Pathways

Recent findings indicate TMEM161A's potential involvement in cell signaling and transport pathways. An important pathway that features TMEM161A activity includes signal transduction where it may interact with proteins like ion channels such as voltage-gated channels. These interactions suggest TMEM161A could modulate responses to cellular environment changes linking it to broader cellular response mechanisms.

Scientists have noted potential links between TMEM161A and neurological disorders. Some studies suggest its involvement in conditions like epilepsy where abnormal ion transport plays a significant role. Alterations in TMEM161A expression might impact channel proteins such as voltage gated potassium channels which are important for maintaining action potentials in neurons potentially exacerbating these conditions. Research continues to explore TMEM161A's full role in these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.

See full target information TMEM161A

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 25:328 PubMed41044542

2025

Tetrahydropalmatine has analgesic role in mouse model of bone cancer pain by inactivating the TNF-α/uPA/PAR2/TRPV1 pathway in dorsal root ganglia.

Applications

Unspecified application

Species

Unspecified reactive species

Guangda Zheng,Linghan Meng,Lu Shang,Juanxia Ren,Dongtao Li,Yanju Bao

Immunity 54:586-602.e8 PubMed33691136

2021

Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery.

Applications

Unspecified application

Species

Unspecified reactive species

Shin-Heng Chiou,Diane Tseng,Alexandre Reuben,Vamsee Mallajosyula,Irene S Molina,Stephanie Conley,Julie Wilhelmy,Alana M McSween,Xinbo Yang,Daisuke Nishimiya,Rahul Sinha,Barzin Y Nabet,Chunlin Wang,Joseph B Shrager,Mark F Berry,Leah Backhus,Natalie S Lui,Heather A Wakelee,Joel W Neal,Sukhmani K Padda,Gerald J Berry,Alberto Delaidelli,Poul H Sorensen,Elena Sotillo,Patrick Tran,Jalen A Benson,Rebecca Richards,Louai Labanieh,Dorota D Klysz,David M Louis,Steven A Feldman,Maximilian Diehn,Irving L Weissman,Jianjun Zhang,Ignacio I Wistuba,P Andrew Futreal,John V Heymach,K Christopher Garcia,Crystal L Mackall,Mark M Davis

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TMEM161A antibody [EPR14369]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM161A antibody [EPR14369] (AB180954)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM161A antibody [EPR14369] (AB180954)

Western blot - Anti-TMEM161A antibody [EPR14369] (AB180954)

Western blot - Anti-TMEM161A antibody [EPR14369] (AB180954)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise