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AB122510

Anti-TMEM164 antibody

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(2 Publications)

Rabbit Polyclonal TMEM164 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM164 aa 1-50.

View Alternative Names

Transmembrane protein 164, Arachidonoyl ether phospholipid synthase, TMEM164

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-TMEM164 antibody (AB122510)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TMEM164 antibody (AB122510)

Immunofluorescent staining of Human cell line U-2 OS shows positivity in vesicles. Recommended concentration of ab122510 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM164 antibody (AB122510)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM164 antibody (AB122510)

ab122510 at 1/150 dilution staining TMEM164 in Paraffin-embedded Human Lung tissue by Immunohistochemistry.

Western blot - Anti-TMEM164 antibody (AB122510)
  • WB

Unknown

Western blot - Anti-TMEM164 antibody (AB122510)

All lanes:

Western blot - Anti-TMEM164 antibody (ab122510) at 1/250 dilution

Lane 1:

RT4 lysate

Lane 2:

U251 MG lysate

Lane 3:

Human plasma

Lane 4:

Human liver lysate

Lane 5:

Human tonsil lysate

Predicted band size: 34 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TMEM164 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q5U3C3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p>pH6.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM164 also known as Transmembrane Protein 164 is a protein that plays a role in cellular mechanisms. It has a molecular mass of about 42 kDa. TMEM164 integrates into cellular membranes with several transmembrane domains contributing to various membrane-associated processes. The protein sees expression across multiple tissues with higher levels observed in areas such as the brain and immune cells suggesting specialized roles in these tissues.
Biological function summary

TMEM164 contributes to the regulation of cellular processes and is associated with complexes that facilitate signal transduction. It might take part in cellular adhesion by influencing the interactions between cells and the extracellular matrix. This can be important for maintaining tissue structure and cellular communication underpinning several physiological functions.

Pathways

TMEM164 interacts functionally within key cellular pathways including the Wnt signaling pathway. In this context it affects cellular proliferation and differentiation processes essential for development and repair mechanisms. Its role may intersect with proteins like β-catenin a critical factor in Wnt signaling indicating a collaborative influence in pathway modulation.

Research links TMEM164 to conditions such as cancer and neurodegenerative disorders. Dysregulation of TMEM164 expression or function may contribute to abnormal cellular proliferation or loss of neuronal integrity. The protein's interactions with key regulators in these disease contexts such as alterations in β-catenin in cancer show its potential impact on disease pathways and make it a target of interest for therapeutic intervention strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Positive regulator of ferroptosis (PubMed : 35947500, PubMed : 36782012). Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20 : 4) of diacylglycerophospholipids, generating C20 : 4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18 : 0/20 : 4)), which promotes ferroptosis (PubMed : 36782012). Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death (PubMed : 35947500).
See full target information TMEM164
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Mediators of inflammation 2025:9021628 PubMed40757051

2025

HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Na An,Mingzhi Xu,Ruman Chen,Cuijuan Wang,Yafei Bai

Journal of Cancer 15:2260-2275 PubMed38495502

2024

Development and Validation of the novel Cuproptosis- and Immune-related Signature for Predicting Prognosis in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yongping Zhang,Ping Sui,Cheng Zhong,Jiansheng Liu
View all publications
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Product promise

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