Anti-TMEM166 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TMEM166 also known as TN601 is a transmembrane protein involved in various cellular processes. It has a molecular mass of approximately 17 kDa. Researchers found TMEM166 expressed in multiple tissues particularly in brain lung and liver. It is located in the membrane structures within the cell contributing to its mechanistic roles in cellular activities where it interacts with other cellular components to influence important processes like autophagy and apoptosis.

Biological function summary

TMEM166 collaborates with cellular components to promote the regulation of cell death and survival. Its involvement in autophagy a process critical for cellular cleanliness and nutrient recycling highlights its role in ensuring cellular homeostasis. TMEM166 may not function as part of a large protein complex but it works in sync with other autophagy and apoptosis-related factors. Its interactions and functionality can influence cellular response to stress helping to maintain balance in cell populations.

Pathways

TMEM166 plays roles that intersect with major cellular processes. It notably contributes to the apoptosis and autophagy pathways. In the apoptosis pathway TMEM166 can interact with factors like BCL-2 family proteins which regulate cell death to influence whether a cell will undergo programmed death. Within the context of autophagy TMEM166 assists in signaling cascades that regulate the formation and maturation of autophagic vesicles. Its activity can therefore modulate critical responses to nutrient availability and stress.

Associated diseases and disorders

TMEM166 exhibits associations with neurodegenerative diseases and certain cancers. Aberrations in TMEM166 expression or function may lead to improper regulation of apoptosis fostering environments conducive to cancer development. In neurodegenerative conditions altered TMEM166 activity might affect neuronal survival through its impact on autophagy and apoptosis contributing to disease progression. Studies have hinted at connections between TMEM166 and proteins like LC3B which is key in autophagosome formation offering insights into the target’s potential clinical relevance.