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AB106597

Anti-Tmem18 antibody

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(1 Publication)

Rabbit Polyclonal Tmem18 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Transmembrane protein 18.

View Alternative Names

Transmembrane protein 18, TMEM18

1 Images
Western blot - Anti-Tmem18 antibody (AB106597)
  • WB

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Western blot - Anti-Tmem18 antibody (AB106597)

Lane 1:

Western blot - Anti-Tmem18 antibody (ab106597) at 0.5 µg/mL

Lane 2:

Western blot - Anti-Tmem18 antibody (ab106597) at 1 µg/mL

All lanes:

Rat brain lysate at 15 µg

Predicted band size: 16 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Transmembrane protein 18. The exact immunogen used to generate this antibody is proprietary information.

Q96B42

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tmem18 also known as Transmembrane Protein 18 is a transmembrane protein with an approximate mass of 17 kDa. It is involved in cellular regulation through its action on chromatin and DNA binding impacting gene expression. Tmem18 is mainly expressed in the brain particularly in the hypothalamus and to a lesser extent in other tissues like adipose (fat) tissue. Current research focuses on the Tmem18's role in neural cell migration and its influence on cellular signaling pathways.
Biological function summary

The protein impacts neural development and energy homeostasis through modulation of transcriptional activities. Tmem18 does not belong to a well-defined complex but it associates with cell surface receptors playing a role in cellular communication and signaling transduction. Through these interactions it alters the expression of genes that control key functions in brain development and energy metabolism notably influencing feeding behavior and energy balance in organisms.

Pathways

Tmem18 associates with both the Wnt signaling pathway and the hypothalamic signaling involved in energy regulation. Its interaction with these pathways influences cellular mechanisms like neural proliferation and differentiation. The protein collaborates with other proteins in these pathways such as beta-catenin in the Wnt pathway and neuropeptide Y in the hypothalamic regulation of appetite highlighting its contribution to cellular and physiological balance.

Tmem18 links to obesity and neurodegenerative conditions. Alterations in Tmem18 expression or function relate to abnormal energy homeostasis contributing to obesity. Furthermore dysregulation in its expression affects neural cells associating it with neurodegenerative diseases. Tmem18 interacts with other proteins involved in such conditions including leptin in the context of obesity and tau proteins in neurodegenerative disorders illustrating its significant role in these areas.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).
See full target information Transmembrane protein 18
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 44:54-74 PubMed39562740

2024

Intestinal NUCB2/nesfatin-1 regulates hepatic glucose production via the MC4R-cAMP-GLP-1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shan Geng,Shan Yang,Xuejiao Tang,Shiyao Xue,Ke Li,Dongfang Liu,Chen Chen,Zhiming Zhu,Hongting Zheng,Yuanqiang Wang,Gangyi Yang,Ling Li,Mengliu Yang
View all publications
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Product promise

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