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AB236852

Anti-TMEM19 antibody

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(1 Publication)

Rabbit Polyclonal TMEM19 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transmembrane protein 19 aa 100 to C-terminus.

View Alternative Names

Transmembrane protein 19, TMEM19

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM19 antibody (AB236852)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM19 antibody (AB236852)

Paraffin-embedded human gastric cancer tissue stained for TMEM19 using ab236852 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-TMEM19 antibody (AB236852)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TMEM19 antibody (AB236852)

A549 (human lung carcinoma cell line) cells stained for TMEM19 (green) using ab236852 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM19 antibody (AB236852)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM19 antibody (AB236852)

Paraffin-embedded human breast cancer tissue stained for TMEM19 using ab236852 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM19 antibody (AB236852)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM19 antibody (AB236852)

Paraffin-embedded human lung tissue stained for TMEM19 using ab236852 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-TMEM19 antibody (AB236852)
  • WB

Supplier Data

Western blot - Anti-TMEM19 antibody (AB236852)

All lanes:

Western blot - Anti-TMEM19 antibody (ab236852) at 1/500 dilution

Lane 1:

MCF7 (human breast adenocarcinoma cell line) whole cell lysate

Lane 2:

U-251 MG (human brain glioma cell line) whole cell lysate

Lane 3:

Mouse stomach lysate

Lane 4:

A549 (human lung carcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Transmembrane protein 19 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96HH6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM19 also known as transmembrane protein 19 is a protein with a molecular mass of approximately 23 kDa. Researchers have identified it as a transmembrane protein common in several tissues including the brain and heart. The protein operates to ensure proper cellular processes by contributing to the structural integrity and communication between cells. It remains important for understanding the role it plays in cell membrane dynamics.
Biological function summary

TMEM19 functions by participating in cellular signaling and membrane organization. It does not act alone often forming complexes with other membrane proteins to stabilize interactions at the cell surface. This role allows it to influence various cellular activities like transport and cellular recognition impacting several physiological functions. Understanding its behavior is important for insights into cellular communication mechanisms.

Pathways

Several studies indicate TMEM19's involvement in pathways related to cellular transport and membrane trafficking. It associates with the endocytosis pathway playing a part in vesicle formation and intracellular signaling. TMEM19 interacts with proteins such as clathrin which is important for these pathways. This connection suggests its importance in maintaining the balance of protein and lipid uptake in cells.

TMEM19 has been linked to neurological impairments and cardiovascular conditions. Mutations or alterations in its expression might relate to disorders like epilepsy and cardiac arrhythmias. It interacts with proteins involved in these conditions such as ion channels and amyloid precursor protein. These associations make TMEM19 a candidate of interest in disease mechanisms and potential therapeutic targeting.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Transmembrane protein 19
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 14:1171308 PubMed37325657

2023

Involvement of CD40-CD40L and ICOS-ICOSL in the development of chronic rhinosinusitis by targeting eosinophils.

Applications

Unspecified application

Species

Unspecified reactive species

Aina Zhou,Chenxi Shi,Yuhui Fan,Yushuang Zheng,Jue Wang,Zhichen Liu,Huanxia Xie,Jisheng Liu,Qingqing Jiao
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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