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AB109468

Anti-TMEM205 antibody

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(1 Publication)

Goat Polyclonal TMEM205 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMEM205 aa 100-150.

View Alternative Names

UNQ501/PRO1018, TMEM205, Transmembrane protein 205

1 Images
Western blot - Anti-TMEM205 antibody (AB109468)
  • WB

Unknown

Western blot - Anti-TMEM205 antibody (AB109468)

Primary incubation was 1 hour.

All lanes:

Western blot - Anti-TMEM205 antibody (ab109468) at 0.03 µg/mL

All lanes:

Human Pancreas lysate (in RIPA buffer) at 35 µg

Predicted band size: 21 kDa

true

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TMEM205 aa 100-150. The exact immunogen used to generate this antibody is proprietary information.

Q6UW68

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.03-0.1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

Reported variants represent identical protein: NP_940938.1, NP_212133.1, NP_001138888.1.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab109468 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.05% Tris buffered saline
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM205 also known as Transmembrane Protein 205 is an integral membrane protein involved in transportation processes across cellular membranes. It weighs approximately 26 kDa and primarily resides in the plasma membranes of cells. TMEM205 is expressed in a broad range of tissues with notable expression in the liver kidney lung and heart. This protein contributes to cellular processes by participating in the movement of various molecules across the cell envelope.
Biological function summary

It plays a role in cellular export mechanisms and likely intersects with the multidrug resistance (MDR) pathways. It does not form part of any larger protein complex but functions independently to modulate cellular response to different substances. Its presence associates with cellular export systems and impacts the ability of the cell to handle xenobiotics which are foreign chemical substances found within an organism.

Pathways

TMEM205 functions in the xenobiotic metabolism regulatory pathways and cellular stress response pathways. It interacts with proteins such as MDR1 (P-glycoprotein) and ABC transporters which are significant in drug resistance mechanisms. These interactions suggest its involvement in detoxification processes allowing cells to expel potentially harmful compounds and adapt to environmental changes.

TMEM205 has been connected to chemotherapy resistance in cancer notably influencing treatment outcomes. Its association with proteins like MDR1 contributes to this resistance by expelling chemotherapeutic agents from cells making treatment less effective. Additionally research indicates it may play a role in certain liver dysfunctions linking it to overall hepatic health and challenging the management of related disorders. Understanding TMEM205's function can aid in developing strategies to counteract drug resistance and support liver health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
See full target information TMEM205
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112742 PubMed40546938

2025

Interferon gamma induced-ACSL5 shapes the lipidome of kidney tubular cells.

Applications

Unspecified application

Species

Unspecified reactive species

Virginie Poindessous,Julio L Sampaio,Lydia Bouidghaghen,Ivan Nemazanyy,Alexandre Pallet,Maarten Naesens,Thibaut Vaulet,Dany Anglicheau,Nicolas Pallet
View all publications
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Product promise

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