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AB121434

Anti-TMEM223 antibody

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(1 Publication)

Rabbit Polyclonal TMEM223 antibody. Suitable for ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM223 aa 100 to C-terminus.

View Alternative Names

Transmembrane protein 223, TMEM223

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-TMEM223 antibody (AB121434)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TMEM223 antibody (AB121434)

Immunocytochemistry/immunofluorescence analysis of human cell line MCF7 labelling TMEN223 with ab121434 at 0.25 μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM223 antibody (AB121434)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM223 antibody (AB121434)

ab121434 staining TMEM223 in paraffin-embedded Human duodenum tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TMEM223 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

A0PJW6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.2-0.25 µg/mL", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM223 also known as Transmembrane Protein 223 is a protein that resides within the membrane and consists of 236 amino acids having an approximate molecular mass of 27 kDa. Researchers have found that TMEM223 is expressed mainly in the brain with lower expression levels detected in tissues like the kidney and liver. The protein is localized in the membrane compartments of cells where it may be involved in cellular processes that require transmembrane activity although its precise mechanical actions remain under investigation.
Biological function summary

The protein plays a role in maintaining cellular homeostasis. It might participate in cellular signaling pathways or interact with other membrane proteins although it is not definitively known to be part of any specific protein complex. Some studies suggest that TMEM223 might influence ion transport or facilitate communication across the cell membrane impacting cellular response to environmental changes or stress.

Pathways

The protein's function appears to connect to neurotransmission and cellular signaling networks. TMEM223 might interact with other proteins like synaptic vesicle-associated proteins within the neurotransmission process facilitating signal propagation in the nervous system. For cellular signaling it potentially engages with pathways involving receptor tyrosine kinases where it could modulate downstream signaling cascades and affect cellular responses to external stimuli.

Research indicates potential implications for TMEM223 in neurodegenerative diseases such as Alzheimer's disease. This connection arises through its probable interaction with proteins like amyloid precursor protein (APP) or tau which play roles in the disease's pathology. Moreover TMEM223 might be involved in kidney pathologies given its expression in renal tissues possibly through its association with proteins implicated in renal function or dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mitochondrial ribosome-associated protein involved in the first steps of cytochrome c oxidase complex (complex IV) biogenesis (PubMed : 34969438). Stimulates the translation of MT-CO1 mRNA and is a constituent of early MT-CO1 assembly intermediates (PubMed : 34969438).
See full target information TMEM223
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of controlled release : official journal of the Controlled Release Society 172:374-381 PubMed24008152

2013

Uptake and transport of B12-conjugated nanoparticles in airway epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Robyn Fowler,Driton Vllasaliu,Franco H Falcone,Martin Garnett,Bryan Smith,Helen Horsley,Cameron Alexander,Snow Stolnik
View all publications
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Product promise

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