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AB126378

Anti-TMEM229B antibody

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(1 Publication)

Rabbit Polyclonal TMEM229B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM229B aa 100 to C-terminus.

View Alternative Names

C14orf83, TMEM229B, Transmembrane protein 229B

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM229B antibody (AB126378)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM229B antibody (AB126378)

ab126378 at 1/50 dilution staining TMEM229B in paraffin-embedded Human cerebral cortex tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TMEM229B aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8NBD8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM229B also known as Transmembrane Protein 229B is a protein with an approximate molecular mass of 41 kDa. This protein is characterized by its multiple transmembrane domains. It extends through the cellular membrane facilitating various interactions. TMEM229B is expressed in several tissues with notable expression in the lungs and liver. The location and structure suggest a role in signal transduction or molecular transport processes across the cell membrane.
Biological function summary

TMEM229B plays a role in cellular homeostasis and signaling. It could interact with other membrane proteins to form complexes that modulate cellular responses to external stimuli. Its involvement in signaling pathways suggests a regulatory function potentially influencing processes like cellular differentiation or proliferation. The biological function emphasizes its importance in maintaining cellular balance and response mechanisms within specific tissues.

Pathways

TMEM229B influences processes such as the MAPK signaling pathway and the PI3K/AKT pathway. These pathways are critical for numerous cellular functions including growth apoptosis and survival. Within these pathways TMEM229B could interact with proteins like EGFR or AKT1 affecting the downstream signaling that governs cellular responses. Understanding its role provides insights into how specific cellular environments control various physiological states.

Researchers have connected TMEM229B to pulmonary diseases and certain cancers. Its altered expression or malfunction might contribute to lung tissue damage or tumor progression. The protein may interact with other proteins such as KRAS in cancer pathways influencing the disease mechanism. Identifying these interactions helps in considering TMEM229B as a potential biomarker or therapeutic target within these pathologies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TMEM229B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eadp4765 PubMed39841844

2025

WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by loss of function.

Applications

Unspecified application

Species

Unspecified reactive species

Xueying Wang,Rui Zhu,Pengcheng Yu,Sixian Qi,Zhenxing Zhong,Ruxin Jin,Yu Wang,Yuan Gu,Dan Ye,Kang Chen,Yilai Shu,Yi Wang,Fa-Xing Yu
View all publications
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